PCLO

piccolo presynaptic cytomatrix protein

Identifier: CI-GENE-00019125
Entity page: /gene/PCLO ↗
Edges: 36

Neighbours: 26 cancers10 variants
Drawn: 36 of 36 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
PCLO has variant …HAS_VARIANTderived10 of 10
→ has variant	NM_033026.6(PCLO):c.13495A>G (p.Ile4499Val)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_033026.6(PCLO):c.13580G>C (p.Ser4527Thr)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed

PCLO altered in cohorts of …ALTERED_INderived26 of 26show fewer
→ altered in cohorts of	Skin Squamous Cell Carcinoma 31 / 39 cases (79 %) · ssm · cscc_hgsc_bcm_2014 · largest of 2 cohorts	—	—	Skin Squamous Cell Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 342 / 470 cases (73 %) · ssm · TCGA-SKCM · largest of 9 cohorts	—	—	Cutaneous Melanoma	9	Observed	gdc	graph →
→ altered in cohorts of	Skin Basal Cell Carcinoma 70 / 126 cases (56 %) · ssm · bcc_unige_2016	—	—	Skin Basal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Melanoma 65 / 144 cases (45 %) · ssm · mel_dfci_2019 · largest of 4 cohorts	—	—	Melanoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Diffuse Large B-Cell Lymphoma Unclassifiable 32 / 135 cases (24 %) · ssm · dlbcl_dfci_2018	—	—	Diffuse Large B-Cell Lymphoma Unclassifiable	1	Observed	cbioportal	graph →
→ altered in cohorts of	Renal Cell Carcinoma 33 / 158 cases (21 %) · ssm · rcc_iatlas_immotion150_2018	—	—	Renal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Endometrioid Adenocarcinoma 51 / 247 cases (21 %) · ssm · uec_cptac_gdc	—	—	Endometrial Endometrioid Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Gastroesophageal Junction Adenocarcinoma 103 / 518 cases (20 %) · ssm · stes_tcga_pub	—	—	Gastroesophageal Junction Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Carcinoma 102 / 517 cases (20 %) · ssm · ucec_tcga_pan_can_atlas_2018 · largest of 4 cohorts	—	—	Endometrial Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Adenocarcinoma 109 / 566 cases (19 %) · ssm · luad_tcga_pan_can_atlas_2018 · largest of 8 cohorts	—	—	Lung Adenocarcinoma	8	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Non-Small Cell Carcinoma 219 / 1,144 cases (19 %) · ssm · nsclc_tcga_broad_2016 · largest of 2 cohorts	—	—	Lung Non-Small Cell Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Squamous Cell Carcinoma 88 / 484 cases (18 %) · ssm · lusc_tcga_pan_can_atlas_2018 · largest of 6 cohorts	—	—	Lung Squamous Cell Carcinoma	6	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Small Cell Carcinoma 21 / 120 cases (18 %) · ssm · sclc_ucologne_2015	—	—	Lung Small Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Colon Adenocarcinoma 73 / 429 cases (17 %) · ssm · coad_tcga_gdc · largest of 3 cohorts	—	—	Colon Adenocarcinoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Gastric Adenocarcinoma 80 / 478 cases (17 %) · ssm · stad_tcga · largest of 4 cohorts	—	—	Gastric Adenocarcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Esophageal Adenocarcinoma 29 / 185 cases (16 %) · ssm · esca_tcga · largest of 4 cohorts	—	—	Esophageal Adenocarcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Head and Neck Squamous Cell Carcinoma 79 / 515 cases (15 %) · ssm · hnsc_tcga_pan_can_atlas_2018 · largest of 4 cohorts	—	—	Head and Neck Squamous Cell Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Hepatocellular Carcinoma 67 / 494 cases (14 %) · ssm · hcc_clca_2024 · largest of 7 cohorts	—	—	Hepatocellular Carcinoma	7	Observed	cbioportal	graph →
→ altered in cohorts of	B-Cell Non-Hodgkin Lymphoma 35 / 297 cases (12 %) · ssm · mbn_sfu_2023	—	—	B-Cell Non-Hodgkin Lymphoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Colorectal Adenocarcinoma 97 / 1,015 cases (9.6 %) · ssm · crc_sysucc_2022 · largest of 3 cohorts	—	—	Colorectal Adenocarcinoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Cholangiocarcinoma 36 / 417 cases (8.6 %) · ssm · chol_icgc_2017	—	—	Cholangiocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Diffuse Glioma 54 / 629 cases (8.6 %) · ssm · difg_glass · largest of 7 cohorts	—	—	Diffuse Glioma	7	Observed	cbioportal	graph →
→ altered in cohorts of	Cervical Squamous Cell Carcinoma 24 / 291 cases (8.2 %) · ssm · cesc_tcga_pan_can_atlas_2018 · largest of 2 cohorts	—	—	Cervical Squamous Cell Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Multiple Myeloma 76 / 961 cases (7.9 %) · ssm · MMRF-COMMPASS	—	—	Multiple Myeloma	1	Observed	gdc	graph →
→ altered in cohorts of	Bladder Urothelial Carcinoma 35 / 474 cases (7.4 %) · ssm · blca_msk_tcga_2020 · largest of 5 cohorts	—	—	Bladder Urothelial Carcinoma	5	Observed	cbioportal	graph →
→ altered in cohorts of	Small Lymphocytic Lymphoma 58 / 1,075 cases (5.4 %) · ssm · cll_broad_2022 · largest of 2 cohorts	—	—	Small Lymphocytic Lymphoma	2	Observed	cbioportal	graph →

PCLO altered in cohorts of …ALTERED_INderived26 of 26show fewer

→ altered in cohorts of

Skin Squamous Cell Carcinoma

31 / 39 cases (79 %) · ssm · cscc_hgsc_bcm_2014 · largest of 2 cohorts

—

Skin Squamous Cell Carcinoma

Observed

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