NTRK3

neurotrophic receptor tyrosine kinase 3

Identifier: CI-GENE-00017361
Entity page: /gene/NTRK3 ↗
Edges: 64

Neighbours: 14 cancers15 variants6 drugs
Drawn: 35 of 35 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

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Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
NTRK3 associated with …ASSOCIATED_WITH15 of 31show all (up to 200)
→ associated with	Solid Neoplasmcancer_family 3 source records aggregated	supports	A	Solid Neoplasm	3	Curated	civic	graph →
→ associated with	Infantile Fibrosarcomasubtype 2 source records aggregated

NTRK3 targets …TARGETS6 of 6
← targets	Taletrectinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Selitrectinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Repotrectinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Lestaurtinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Larotrectinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Entrectinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →

NTRK3 targets …TARGETS6 of 6

← targets

Taletrectinibsmall_molecule

—

INHIBITOR

—

Curated

NTRK3 has variant …HAS_VARIANTderived15 of 23show all (up to 200)
→ has variant	Fusionfusion 32 accepted CIViC evidence items	—	—	Malignant Neoplasm,Solid Neoplasm,Congenital Mesoblastic Nephroma+2	32	Curated	civic	graph →
→ has variant	Fusionfusion 17 accepted CIViC evidence items	—	—	Congenital Mesoblastic Nephroma,Glioblastoma,Cervical Sarcoma+2	17	Curated	civic	graph →
→ has variant	Fusionfusion 4 accepted CIViC evidence items	—	—	Malignant Neoplasm,Solid Neoplasm	4	Curated	civic	graph →
→ has variant	G623RSNV 4 accepted CIViC evidence items	—	—	Malignant Neoplasm,Lung Non-Small Cell Carcinoma	4	Curated	civic	graph →
→ has variant	Amplificationamplification 2 accepted CIViC evidence items	—	—	Malignant Neoplasm	2	Curated	civic	graph →
→ has variant	e1::e4fusion 1 accepted CIViC evidence items	—	—	Osteosarcoma	1	Curated	civic	graph →
→ has variant	e4::e1fusion 1 accepted CIViC evidence items	—	—	Osteosarcoma	1	Curated	civic	graph →
→ has variant	e4::e18fusion 1 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ has variant	F617LSNV 1 accepted CIViC evidence items	—	—	Gastrointestinal Stromal Tumor	1	Curated	civic	graph →
→ has variant	Fusionfusion 1 accepted CIViC evidence items	—	—	Melanoma	1	Curated	civic	graph →
→ has variant	EXPRESSIONexpression no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Fusionfusion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Fusionfusion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Fusionfusion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Fusionfusion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

NTRK3 altered in cohorts of …ALTERED_INderived4 of 4
→ altered in cohorts of	Cutaneous Melanoma 102 / 696 cases (15 %) · ssm · mel_mskimpact_2020	—	—	Cutaneous Melanoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Non-Small Cell Carcinomasubtype 35 / 447 cases (7.8 %) · ssm · nsclc_tracerx_2017	—	—	Lung Non-Small Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Multiple Myeloma 64 / 961 cases (6.7 %) · ssm · MMRF-COMMPASS	—	—	Multiple Myeloma	1	Observed	gdc	graph →
→ altered in cohorts of	Lung Adenocarcinoma 155 / 2,653 cases (5.8 %) · ssm · luad_mskcc_2023_met_organotropism · largest of 3 cohorts	—	—	Lung Adenocarcinoma	3	Observed	cbioportal	graph →

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