NTRK3 Fusion

CI-VAR-00001407Explore in graph →CIViC 4722

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Neoplasm1
SPECC1L::NTRK3 Fusion	Larotrectinib	Predictive	C	Supports Sensitivity Response	4	submitted	EID11745 A six month old M infant had a left upper extremity mass. The histology indicated mesenchymal neoplasm and no ETV6 rearrangement was found with FISH. Copy number aberrations were found together with T… (full text at CIViC) PMID 34036219 · Zhao et al., 2021 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.