MYH11

myosin heavy chain 11

Identifier: CI-GENE-00015992
Entity page: /gene/MYH11 ↗
Edges: 24

Neighbours: 5 cancers15 variants
Drawn: 20 of 20 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
MYH11 associated with …ASSOCIATED_WITH2 of 2
→ associated with	Acute Myeloid Leukemia with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11molecular_subtype 3 source records aggregated	supports	B	Acute Myeloid Leukemia with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11	3	Curated	civic	graph →
associated with

MYH11 has variant …HAS_VARIANTderived15 of 19show all (up to 200)
→ has variant	Fusionfusion 4 accepted CIViC evidence items	—	—	Acute Myeloid Leukemia,Acute Myeloid Leukemia with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11	4	Curated	civic	graph →
→ has variant	NM_001040113.2(MYH11):c.654+1G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002474.3(MYH11):c.1017C>T (p.Ser339=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002474.3(MYH11):c.1032A>G (p.Leu344=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002474.3(MYH11):c.1032A>T (p.Leu344=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002474.3(MYH11):c.1129+41T>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002474.3(MYH11):c.1743T>A (p.Ala581=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002474.3(MYH11):c.2412-9C>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002474.3(MYH11):c.3293+94C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002474.3(MYH11):c.3651+37A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002474.3(MYH11):c.3757AAG[3] (p.Lys1256del)other no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002474.3(MYH11):c.4045C>T (p.Gln1349Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002474.3(MYH11):c.4791+5G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002474.3(MYH11):c.4792-15C>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002474.3(MYH11):c.4954-18_4954-15deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

MYH11 has variant …HAS_VARIANTderived15 of 19show all (up to 200)

→ has variant

Fusionfusion

4 accepted CIViC evidence items

—

Acute Myeloid Leukemia,Acute Myeloid Leukemia with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11

Curated

MYH11 altered in cohorts of …ALTERED_INderived3 of 3
→ altered in cohorts of	Endometrial Endometrioid Adenocarcinoma 27 / 247 cases (11 %) · ssm · uec_cptac_gdc	—	—	Endometrial Endometrioid Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Colorectal Adenocarcinoma 20 / 224 cases (8.9 %) · ssm · coadread_tcga_pub · largest of 2 cohorts	—	—	Colorectal Adenocarcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Non-Small Cell Carcinoma 36 / 447 cases (8.1 %) · ssm · nsclc_tracerx_2017	—	—	Lung Non-Small Cell Carcinoma	1	Observed	cbioportal	graph →

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