MUC16

mucin 16, cell surface associated

Identifier: CI-GENE-00015908
Entity page: /gene/MUC16 ↗
Edges: 60

Neighbours: 35 cancers15 variants
Drawn: 50 of 50 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
MUC16 has variant …HAS_VARIANTderived15 of 25show all (up to 200)
→ has variant	NM_001401501.2(MUC16):c.1098T>C (p.Ala366=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001401501.2(MUC16):c.11596G>T (p.Gly3866Trp)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0

MUC16 altered in cohorts of …ALTERED_INderived35 of 35show fewer
→ altered in cohorts of	Skin Basal Cell Carcinoma 103 / 126 cases (82 %) · ssm · bcc_unige_2016	—	—	Skin Basal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 377 / 470 cases (80 %) · ssm · TCGA-SKCM · largest of 9 cohorts	—	—	Cutaneous Melanoma	9	Observed	gdc	graph →
→ altered in cohorts of	Lung Adenocarcinoma 376 / 573 cases (66 %) · ssm · TCGA-LUAD · largest of 11 cohorts	—	—	Lung Adenocarcinoma	11	Observed	gdc	graph →
→ altered in cohorts of	Melanoma 86 / 144 cases (60 %) · ssm · mel_dfci_2019 · largest of 5 cohorts	—	—	Melanoma	5	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Carcinoma 266 / 559 cases (48 %) · ssm · TCGA-UCEC · largest of 5 cohorts	—	—	Endometrial Carcinoma	5	Observed	gdc	graph →
→ altered in cohorts of	Lung Small Cell Carcinoma 49 / 120 cases (41 %) · ssm · sclc_ucologne_2015	—	—	Lung Small Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Non-Small Cell Carcinoma 463 / 1,144 cases (40 %) · ssm · nsclc_tcga_broad_2016 · largest of 3 cohorts	—	—	Lung Non-Small Cell Carcinoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Squamous Cell Carcinoma 188 / 484 cases (39 %) · ssm · lusc_tcga_pan_can_atlas_2018 · largest of 6 cohorts	—	—	Lung Squamous Cell Carcinoma	6	Observed	cbioportal	graph →
→ altered in cohorts of	Skin Squamous Cell Carcinoma 32 / 83 cases (39 %) · ssm · cscc_ucsf_2021 · largest of 3 cohorts	—	—	Skin Squamous Cell Carcinoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Gastroesophageal Junction Adenocarcinoma 171 / 518 cases (33 %) · ssm · stes_tcga_pub	—	—	Gastroesophageal Junction Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Colon Adenocarcinoma 121 / 429 cases (28 %) · ssm · coad_tcga_gdc · largest of 4 cohorts	—	—	Colon Adenocarcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Gastric Adenocarcinoma 134 / 478 cases (28 %) · ssm · stad_tcga · largest of 6 cohorts	—	—	Gastric Adenocarcinoma	6	Observed	cbioportal	graph →
→ altered in cohorts of	Esophageal Adenocarcinoma 51 / 185 cases (28 %) · ssm · esca_tcga · largest of 4 cohorts	—	—	Esophageal Adenocarcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Adrenal Cortical Carcinoma 22 / 90 cases (24 %) · ssm · acc_tcga	—	—	Adrenal Cortical Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Bladder Urothelial Carcinoma 101 / 474 cases (21 %) · ssm · blca_msk_tcga_2020 · largest of 7 cohorts	—	—	Bladder Urothelial Carcinoma	7	Observed	cbioportal	graph →
→ altered in cohorts of	Head and Neck Carcinoma, Other 23 / 108 cases (21 %) · ssm · ohnca_cptac_gdc	—	—	Head and Neck Carcinoma, Other	1	Observed	cbioportal	graph →
→ altered in cohorts of	Hepatocellular Carcinoma 105 / 494 cases (21 %) · ssm · hcc_clca_2024 · largest of 6 cohorts	—	—	Hepatocellular Carcinoma	6	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Endometrioid Adenocarcinoma 49 / 247 cases (20 %) · ssm · uec_cptac_gdc	—	—	Endometrial Endometrioid Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Head and Neck Squamous Cell Carcinoma 101 / 515 cases (20 %) · ssm · hnsc_tcga_pan_can_atlas_2018 · largest of 4 cohorts	—	—	Head and Neck Squamous Cell Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Rectal Adenocarcinoma 28 / 155 cases (18 %) · ssm · read_tcga_gdc	—	—	Rectal Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Invasive Breast Carcinoma 409 / 2,433 cases (17 %) · ssm · brca_metabric · largest of 9 cohorts	—	—	Invasive Breast Carcinoma	9	Observed	cbioportal	graph →
→ altered in cohorts of	Cervical Squamous Cell Carcinoma 48 / 291 cases (16 %) · ssm · cesc_tcga_pan_can_atlas_2018 · largest of 3 cohorts	—	—	Cervical Squamous Cell Carcinoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Colorectal Adenocarcinoma 167 / 1,015 cases (16 %) · ssm · crc_sysucc_2022 · largest of 6 cohorts	—	—	Colorectal Adenocarcinoma	6	Observed	cbioportal	graph →
→ altered in cohorts of	Combined Hepatocellular Carcinoma and Cholangiocarcinoma 25 / 173 cases (14 %) · ssm · hccihch_pku_2019	—	—	Combined Hepatocellular Carcinoma and Cholangiocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Esophageal Squamous Cell Carcinoma 20 / 139 cases (14 %) · ssm · escc_ucla_2014	—	—	Esophageal Squamous Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	B-Cell Non-Hodgkin Lymphoma 39 / 297 cases (13 %) · ssm · mbn_sfu_2023	—	—	B-Cell Non-Hodgkin Lymphoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Clear Cell Renal Cell Carcinoma 58 / 451 cases (13 %) · ssm · kirc_tcga · largest of 4 cohorts	—	—	Clear Cell Renal Cell Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Prostate Adenocarcinoma 113 / 1,013 cases (11 %) · ssm · prad_p1000 · largest of 7 cohorts	—	—	Prostate Adenocarcinoma	7	Observed	cbioportal	graph →
→ altered in cohorts of	Multiple Myeloma 102 / 961 cases (11 %) · ssm · MMRF-COMMPASS	—	—	Multiple Myeloma	1	Observed	gdc	graph →
→ altered in cohorts of	Cholangiocarcinoma 44 / 417 cases (11 %) · ssm · chol_icgc_2017	—	—	Cholangiocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Papillary Renal Cell Carcinoma 24 / 282 cases (8.5 %) · ssm · kirp_tcga · largest of 3 cohorts	—	—	Papillary Renal Cell Carcinoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Diffuse Glioma 69 / 812 cases (8.5 %) · ssm · lgggbm_tcga_pub · largest of 10 cohorts	—	—	Diffuse Glioma	10	Observed	cbioportal	graph →
→ altered in cohorts of	High-Grade Serous Ovarian Cancer 41 / 523 cases (7.8 %) · ssm · ov_tcga_pan_can_atlas_2018 · largest of 2 cohorts	—	—	High-Grade Serous Ovarian Cancer	2	Observed	cbioportal	graph →
→ altered in cohorts of	Renal Cell Carcinoma 20 / 352 cases (5.7 %) · ssm · rcc_cptac_gdc · largest of 2 cohorts	—	—	Renal Cell Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Pancreatic Adenocarcinoma 20 / 383 cases (5.2 %) · ssm · paad_qcmg_uq_2016	—	—	Pancreatic Adenocarcinoma	1	Observed	cbioportal	graph →

MUC16 altered in cohorts of …ALTERED_INderived35 of 35show fewer

→ altered in cohorts of

Skin Basal Cell Carcinoma

103 / 126 cases (82 %) · ssm · bcc_unige_2016

—

Skin Basal Cell Carcinoma

Observed

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