MET

MET proto-oncogene, receptor tyrosine kinase

Identifier: CI-GENE-00012412
Entity page: /gene/MET ↗
Edges: 4,829

Neighbours: 11 cancers15 variants10 drugs
Drawn: 36 of 36 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
MET associated with …ASSOCIATED_WITH16 of 16show fewer
→ associated with	Lung Non-Small Cell Carcinomasubtype	supports	A	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ associated with	Lung Non-Small Cell Carcinomasubtype 2 source records aggregated

MET targets …TARGETS10 of 10
← targets	Tepotinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Savolitinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Onartuzumabmonoclonal_antibody	—	ANTAGONIST	—	1	Curated	chembl	graph →
← targets	Ningetinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Foretinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Crizotinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Capmatinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Cabozantinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Amuvatinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Amivantamabmonoclonal_antibody	—	INHIBITOR	—	1	Curated	chembl	graph →

MET targets …TARGETS10 of 10

← targets

Tepotinibsmall_molecule

—

INHIBITOR

—

Curated

MET has variant …HAS_VARIANTderived15 of 4,799show all (up to 200)
→ has variant	Amplificationamplification 15 accepted CIViC evidence items	—	—	Malignant Neoplasm,Glioblastoma,Lung Non-Small Cell Carcinoma+2	15	Curated	civic	graph →
→ has variant	Exon 14 Skipping Mutationdeletion_cna 12 accepted CIViC evidence items	—	—	Malignant Neoplasm,Lung Non-Small Cell Carcinoma,Lung Adenocarcinoma	12	Curated	civic	graph →
→ has variant	Overexpressionexpression 5 accepted CIViC evidence items	—	—	Cutaneous Melanoma,Uveal Melanoma,Gastric Adenocarcinoma	5	Curated	civic	graph →
→ has variant	D1228VSNV 2 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	2	Curated	civic	graph →
→ has variant	D1228NSNV 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	Mutationother 1 accepted CIViC evidence items	—	—	Papillary Renal Cell Carcinoma	1	Curated	civic	graph →
→ has variant	R1004GSNV 1 accepted CIViC evidence items	—	—	Malignant Head and Neck Neoplasm	1	Curated	civic	graph →
→ has variant	Splice Site (c.3028G>A)splice 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	D1010HSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	D1010NSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	D1010YSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	D963ESNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	e24::e15fusion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Exon 14 Mutation no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Fusionfusion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

MET altered in cohorts of …ALTERED_INderived4 of 4
→ altered in cohorts of	Cutaneous Melanomacancer 82 / 696 cases (12 %) · ssm · mel_mskimpact_2020	—	—	Cutaneous Melanoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Papillary Renal Cell Carcinomasubtype 21 / 282 cases (7.4 %) · ssm · kirp_tcga · largest of 3 cohorts	—	—	Papillary Renal Cell Carcinoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Adenocarcinomasubtype 34 / 604 cases (5.6 %) · ssm · luad_mskcc_2020 · largest of 2 cohorts	—	—	Lung Adenocarcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Non-Small Cell Carcinomasubtype 134 / 2,621 cases (5.1 %) · ssm · nsclc_ctdx_msk_2022	—	—	Lung Non-Small Cell Carcinoma	1	Observed	cbioportal	graph →

Radial view

Every edge, grouped by relationship

Paths