MET Splice Site (c.3028G>A)

CI-VAR-00004211Explore in graph →NM_000245.4:c.3028G>AClinVar 983225 CIViC 4386 rs1794851612

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Lung Non-Small Cell Carcinoma1
MET Amplification AND MET Splice Site (c.3028G>A)	Crizotinib	Predictive	C	Supports Sensitivity Response	3	accepted	EID1095 64-year old female (non-smoker) was diagnosed with NSCLC. A c.3028 G->A mutation was identified in exon 14 resulting in exon 14 skipping. Further, amplification of the MET gene was observed. The patie… (full text at CIViC) PMID 26729443 · Awad et al., 2016 · Open in CIViC	civic

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
983225	Uncertain significance	criteria provided, single submitter	1	Lung carcinoma; Hereditary cancer-predisposing syndrome; Diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype	germline/somatic	3	Mar 30, 2022	clinvar