MET D1010H

CI-VAR-00000394Explore in graph →ENST00000397752.3:c.3028G>CCIViC 1660

Curated evidence

Evidence by cancer (3 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–3 of 3 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Lung Adenocarcinoma2
MET D1010H	Crizotinib	Predictive	C	Supports Sensitivity Response	—	submitted	EID4792 In a lung adenocarcinoma patient harboring MET D1028H mutation, a partial response to crizotinib treatment was reported with continued response for at least 6 months. Prior to crizotinib treatment, th… (full text at CIViC) PMID 25898962 · Waqar et al., 2015 · Open in CIViC	civic
MET D1010H	Crizotinib	Predictive	C	Supports Sensitivity Response	—	submitted	EID4793 In a lung adenocarcinoma patient harboring a MET D1010H mutation, stable disease to crizotinib monotherapy was reported. The patient was treated with crizotinib for 4 months; treatment was ongoing at … (full text at CIViC) PMID 27343443 · Schrock et al., 2016 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Lung Non-Small Cell Carcinoma1
MDM2 Amplification AND MET D1010H	Crizotinib	Predictive	C	Supports Sensitivity Response	3	submitted	EID11374 A 76-year old female (former light smoker) diagnosed with metastatic squamous lung carcinoma was found to have MET D1010H and MDM2 mutation following mutation analysis. She was originally treated with… (full text at CIViC) PMID 25898965 · Mendenhall et al., 2015 · Open in CIViC	civic