LRP1B

LDL receptor related protein 1B

Identifier: CI-GENE-00010494
Entity page: /gene/LRP1B ↗
Edges: 59

Neighbours: 29 cancers15 variants
Drawn: 44 of 44 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
LRP1B associated with …ASSOCIATED_WITH4 of 4
→ associated with	Lung Adenocarcinomasubtype	supports	B	Lung Adenocarcinoma	1	Curated	civic	graph →
→ associated with	Solid Neoplasmcancer_family	supports	B

LRP1B has variant …HAS_VARIANTderived15 of 29show all (up to 200)
→ has variant	Loss-of-function 2 accepted CIViC evidence items	—	—	Solid Neoplasm,Lung Adenocarcinoma	2	Curated	civic	graph →
→ has variant	Deletiondeletion_cna 1 accepted CIViC evidence items	—	—	Glioblastoma	1	Curated	civic	graph →
→ has variant	Exon 12-22 Deletiondeletion_cna 1 accepted CIViC evidence items	—	—	Malignant Ovarian Neoplasm	1	Curated	civic	graph →
→ has variant	Alterations no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_018557.3(LRP1B):c.10187G>C (p.Cys3396Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_018557.3(LRP1B):c.10193C>G (p.Ser3398Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_018557.3(LRP1B):c.11006G>T (p.Arg3669Ile)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_018557.3(LRP1B):c.11727C>T (p.Gly3909=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_018557.3(LRP1B):c.1842C>G (p.Tyr614Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_018557.3(LRP1B):c.2005A>G (p.Ile669Val)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_018557.3(LRP1B):c.2190+3A>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_018557.3(LRP1B):c.3072C>A (p.Ala1024=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_018557.3(LRP1B):c.3416C>A (p.Pro1139His)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_018557.3(LRP1B):c.4163G>A (p.Arg1388Lys)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_018557.3(LRP1B):c.4171A>T (p.Ile1391Phe)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

LRP1B has variant …HAS_VARIANTderived15 of 29show all (up to 200)

→ has variant

Loss-of-function

2 accepted CIViC evidence items

—

Solid Neoplasm,Lung Adenocarcinoma

Curated

LRP1B altered in cohorts of …ALTERED_INderived26 of 26show fewer
→ altered in cohorts of	Skin Basal Cell Carcinoma 197 / 293 cases (67 %) · ssm · bcc_unige_2016	—	—	Skin Basal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Skin Squamous Cell Carcinoma 37 / 83 cases (45 %) · ssm · cscc_ucsf_2021 · largest of 3 cohorts	—	—	Skin Squamous Cell Carcinoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Small Cell Carcinoma 51 / 120 cases (43 %) · ssm · sclc_ucologne_2015	—	—	Lung Small Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Melanoma 57 / 144 cases (40 %) · ssm · mel_dfci_2019 · largest of 4 cohorts	—	—	Melanoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 182 / 469 cases (39 %) · ssm · skcm_tcga_gdc · largest of 9 cohorts	—	—	Cutaneous Melanoma	9	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Adenocarcinomasubtype 201 / 566 cases (36 %) · ssm · luad_tcga_pan_can_atlas_2018 · largest of 9 cohorts	—	—	Lung Adenocarcinoma	9	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Squamous Cell Carcinoma 171 / 484 cases (35 %) · ssm · lusc_tcga_pan_can_atlas_2018 · largest of 6 cohorts	—	—	Lung Squamous Cell Carcinoma	6	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Non-Small Cell Carcinoma 402 / 1,144 cases (35 %) · ssm · nsclc_tcga_broad_2016 · largest of 2 cohorts	—	—	Lung Non-Small Cell Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Gastroesophageal Junction Adenocarcinoma 125 / 518 cases (24 %) · ssm · stes_tcga_pub	—	—	Gastroesophageal Junction Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Gastric Adenocarcinoma 104 / 478 cases (22 %) · ssm · stad_tcga · largest of 5 cohorts	—	—	Gastric Adenocarcinoma	5	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Carcinoma 99 / 517 cases (19 %) · ssm · ucec_tcga_pan_can_atlas_2018 · largest of 4 cohorts	—	—	Endometrial Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Esophageal Adenocarcinoma 33 / 185 cases (18 %) · ssm · esca_tcga · largest of 4 cohorts	—	—	Esophageal Adenocarcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Renal Cell Carcinoma 28 / 158 cases (18 %) · ssm · rcc_iatlas_immotion150_2018	—	—	Renal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Colon Adenocarcinoma 75 / 429 cases (17 %) · ssm · coad_tcga_gdc · largest of 2 cohorts	—	—	Colon Adenocarcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Head and Neck Squamous Cell Carcinoma 85 / 515 cases (17 %) · ssm · hnsc_tcga_pan_can_atlas_2018 · largest of 4 cohorts	—	—	Head and Neck Squamous Cell Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Rectal Adenocarcinoma 24 / 155 cases (15 %) · ssm · read_tcga_gdc	—	—	Rectal Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	B-Cell Non-Hodgkin Lymphoma 96 / 755 cases (13 %) · ssm · mbn_mdacc_2013 · largest of 2 cohorts	—	—	B-Cell Non-Hodgkin Lymphoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Hepatocellular Carcinoma 59 / 494 cases (12 %) · ssm · hcc_clca_2024 · largest of 4 cohorts	—	—	Hepatocellular Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Cervical Squamous Cell Carcinoma 33 / 291 cases (11 %) · ssm · cesc_tcga_pan_can_atlas_2018 · largest of 2 cohorts	—	—	Cervical Squamous Cell Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Colorectal Adenocarcinoma 105 / 1,015 cases (10 %) · ssm · crc_sysucc_2022 · largest of 6 cohorts	—	—	Colorectal Adenocarcinoma	6	Observed	cbioportal	graph →
→ altered in cohorts of	Cholangiocarcinoma 39 / 417 cases (9.4 %) · ssm · chol_icgc_2017	—	—	Cholangiocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Bladder Urothelial Carcinoma 40 / 474 cases (8.4 %) · ssm · blca_msk_tcga_2020 · largest of 6 cohorts	—	—	Bladder Urothelial Carcinoma	6	Observed	cbioportal	graph →
→ altered in cohorts of	Multiple Myeloma 73 / 961 cases (7.6 %) · ssm · MMRF-COMMPASS	—	—	Multiple Myeloma	1	Observed	gdc	graph →
→ altered in cohorts of	Diffuse Glioma 41 / 629 cases (6.5 %) · ssm · difg_glass · largest of 2 cohorts	—	—	Diffuse Glioma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Pancreatic Adenocarcinoma 22 / 383 cases (5.7 %) · ssm · paad_qcmg_uq_2016	—	—	Pancreatic Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Prostate Adenocarcinoma 54 / 1,013 cases (5.3 %) · ssm · prad_p1000 · largest of 2 cohorts	—	—	Prostate Adenocarcinoma	2	Observed	cbioportal	graph →

Radial view

Every edge, grouped by relationship

Paths