KMT2C

lysine methyltransferase 2C

Identifier: CI-GENE-00007113
Entity page: /gene/KMT2C ↗
Edges: 97

Neighbours: 32 cancers15 variants
Drawn: 47 of 47 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
KMT2C associated with …ASSOCIATED_WITH3 of 3
→ associated with	Malignant Breast Neoplasmcancer_family	supports	B	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ associated with	Skin Squamous Cell Carcinomasubtype	supports	B

KMT2C has variant …HAS_VARIANTderived15 of 64show all (up to 200)
→ has variant	Mutationother 2 accepted CIViC evidence items	—	—	Malignant Neoplasm,Skin Squamous Cell Carcinoma	2	Curated	civic	graph →
→ has variant	Lossdeletion_cna 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	Loss-of-function no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_170606.3(KMT2C):c.1081A>G (p.Thr361Ala)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_170606.3(KMT2C):c.10880C>G (p.Ser3627Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_170606.3(KMT2C):c.11207T>A (p.Leu3736Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_170606.3(KMT2C):c.11405A>G (p.Asp3802Gly)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_170606.3(KMT2C):c.11812+1G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_170606.3(KMT2C):c.11961-14T>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_170606.3(KMT2C):c.12227G>C (p.Arg4076Thr)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_170606.3(KMT2C):c.12277-1G>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_170606.3(KMT2C):c.12444G>T (p.Pro4148=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_170606.3(KMT2C):c.12755C>T (p.Ala4252Val)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_170606.3(KMT2C):c.13305G>A (p.Trp4435Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_170606.3(KMT2C):c.13645C>T (p.Arg4549Cys)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

KMT2C has variant …HAS_VARIANTderived15 of 64show all (up to 200)

→ has variant

Mutationother

2 accepted CIViC evidence items

—

Malignant Neoplasm,Skin Squamous Cell Carcinoma

Curated

KMT2C altered in cohorts of …ALTERED_INderived30 of 30show fewer
→ altered in cohorts of	Skin Basal Cell Carcinoma 47 / 126 cases (37 %) · ssm · bcc_unige_2016	—	—	Skin Basal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Skin Squamous Cell Carcinomasubtype 27 / 83 cases (33 %) · ssm · cscc_ucsf_2021	—	—	Skin Squamous Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Renal Pelvis and Ureter Urothelial Carcinoma 27 / 119 cases (23 %) · ssm · utuc_msk_2019 · largest of 2 cohorts	—	—	Renal Pelvis and Ureter Urothelial Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Cervical Squamous Cell Carcinoma 54 / 291 cases (19 %) · ssm · cesc_tcga_pan_can_atlas_2018 · largest of 3 cohorts	—	—	Cervical Squamous Cell Carcinoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 124 / 696 cases (18 %) · ssm · mel_mskimpact_2020 · largest of 3 cohorts	—	—	Cutaneous Melanoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Bladder Urothelial Carcinoma 80 / 474 cases (17 %) · ssm · blca_msk_tcga_2020 · largest of 10 cohorts	—	—	Bladder Urothelial Carcinoma	10	Observed	cbioportal	graph →
→ altered in cohorts of	Melanoma 20 / 122 cases (16 %) · ssm · mel_iatlas_liu_2019	—	—	Melanoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Non-Small Cell Carcinoma 182 / 1,144 cases (16 %) · ssm · nsclc_tcga_broad_2016 · largest of 3 cohorts	—	—	Lung Non-Small Cell Carcinoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Endometrioid Adenocarcinoma 37 / 247 cases (15 %) · ssm · uec_cptac_gdc	—	—	Endometrial Endometrioid Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Squamous Cell Carcinoma 71 / 484 cases (15 %) · ssm · lusc_tcga_pan_can_atlas_2018 · largest of 4 cohorts	—	—	Lung Squamous Cell Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Gastroesophageal Junction Adenocarcinoma 66 / 518 cases (13 %) · ssm · stes_tcga_pub	—	—	Gastroesophageal Junction Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Colon Adenocarcinoma 50 / 429 cases (12 %) · ssm · coad_tcga_gdc · largest of 2 cohorts	—	—	Colon Adenocarcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Gastric Adenocarcinoma 55 / 478 cases (12 %) · ssm · stad_tcga · largest of 4 cohorts	—	—	Gastric Adenocarcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Adenoid Cystic Carcinoma 99 / 1,049 cases (9.4 %) · ssm · acc_2019	—	—	Adenoid Cystic Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Invasive Breast Carcinoma 357 / 3,879 cases (9.2 %) · ssm · breast_msk_2025 · largest of 9 cohorts	—	—	Invasive Breast Carcinoma	9	Observed	cbioportal	graph →
→ altered in cohorts of	Rectal Adenocarcinoma 605 / 7,237 cases (8.4 %) · ssm · crc_msk_2026	—	—	Rectal Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Gallbladder Carcinoma 20 / 244 cases (8.2 %) · ssm · gbc_mskcc_2022	—	—	Gallbladder Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Head and Neck Squamous Cell Carcinoma 37 / 515 cases (7.2 %) · ssm · hnsc_tcga_pan_can_atlas_2018 · largest of 4 cohorts	—	—	Head and Neck Squamous Cell Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Cholangiocarcinoma 29 / 417 cases (7.0 %) · ssm · chol_icgc_2017	—	—	Cholangiocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Prostate Adenocarcinoma 140 / 2,069 cases (6.8 %) · ssm · prad_msk_stopsack_2021 · largest of 10 cohorts	—	—	Prostate Adenocarcinoma	10	Observed	cbioportal	graph →
→ altered in cohorts of	Diffuse Glioma 42 / 629 cases (6.7 %) · ssm · difg_glass · largest of 2 cohorts	—	—	Diffuse Glioma	2	Observed	cbioportal	graph →
→ altered in cohorts of	B-Cell Non-Hodgkin Lymphoma 46 / 755 cases (6.1 %) · ssm · mbn_mdacc_2013	—	—	B-Cell Non-Hodgkin Lymphoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Colorectal Adenocarcinoma 68 / 1,134 cases (6.0 %) · ssm · crc_msk_2017 · largest of 4 cohorts	—	—	Colorectal Adenocarcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Adenocarcinoma 158 / 2,653 cases (6.0 %) · ssm · luad_mskcc_2023_met_organotropism · largest of 8 cohorts	—	—	Lung Adenocarcinoma	8	Observed	cbioportal	graph →
→ altered in cohorts of	Medulloblastoma 29 / 491 cases (5.9 %) · ssm · mbl_dkfz_2017	—	—	Medulloblastoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Diffuse Large B-Cell Lymphoma Unclassifiable 56 / 1,001 cases (5.6 %) · ssm · dlbcl_duke_2017	—	—	Diffuse Large B-Cell Lymphoma Unclassifiable	1	Observed	cbioportal	graph →
→ altered in cohorts of	Pancreatic Adenocarcinoma 21 / 383 cases (5.5 %) · ssm · paad_qcmg_uq_2016	—	—	Pancreatic Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Carcinoma 96 / 1,882 cases (5.1 %) · ssm · ucec_ancestry_cds_msk_2023 · largest of 7 cohorts	—	—	Endometrial Carcinoma	7	Observed	cbioportal	graph →
→ altered in cohorts of	Myelodysplastic Syndrome 168 / 3,323 cases (5.1 %) · ssm · mds_iwg_2022	—	—	Myelodysplastic Syndrome	1	Observed	cbioportal	graph →
→ altered in cohorts of	Hepatocellular Carcinoma 69 / 1,370 cases (5.0 %) · ssm · hcc_msk_2024 · largest of 2 cohorts	—	—	Hepatocellular Carcinoma	2	Observed	cbioportal	graph →

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