KMT2C Loss-of-function

CI-VAR-00002536Explore in graph →CIViC 2424

Curated evidence

Evidence by cancer (3 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–3 of 3 evidence items across 3 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Bladder Carcinoma1
KMT2C Loss-of-function	Olaparib	Predictive	D	Supports Sensitivity Response	2	submitted	EID12773 In preclinical xenograft models derived from KMT2C-deficient tumors (HTB9 BC, H1437 NSCLC, T84 COAD, Cal-33 HNSCC), PARP1/2 inhibition with olaparib significantly reduced tumor growth compared to KMT2… (full text at CIViC) PMID 30665945 · Rampias et al., 2019 · Open in CIViC	civic
Urothelial Carcinoma1
KMT2D Loss-of-function OR KMT2C Loss-of-function	Afatinib + GefitinibSubstitutes	Predictive	D	Supports Sensitivity Response	2	submitted	EID12775 In preclinical urothelial carcinoma (UC) models, combined loss of KMT2C/KMT2D increased sensitivity to EGFR inhibitors, with Kmt2c/d-deficient cells showing significantly reduced IC50 values for afati…

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Unmapped disease1unmapped disease
KMT2C Loss-of-function	(functional)	Functional	B	Supports Loss Of Function	2	submitted	EID12772 In a bladder cancer cohort with matched tumor–normal samples (n = 104), KMT2C expression was significantly reduced in tumors compared to normal tissue (71/104 pairs; p < 0.001). shRNA-mediated KMT2C … (full text at CIViC) PMID 30665945 · Rampias et al., 2019 · Open in CIViC	civic