HRAS

HRas proto-oncogene, GTPase

Identifier: CI-GENE-00005011
Entity page: /gene/HRAS ↗
Edges: 65

Neighbours: 5 cancers15 variants1 drugs
Drawn: 21 of 21 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
HRAS associated with …ASSOCIATED_WITH6 of 6
→ associated with	Head and Neck Squamous Cell Carcinomasubtype	supports	B	Head and Neck Squamous Cell Carcinoma	1	Curated	civic	graph →
→ associated with	Bladder Urothelial Carcinomasubtype	supports

HRAS targets …TARGETS1 of 1
← targets	Salirasibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →

HRAS has variant …HAS_VARIANTderived15 of 57show all (up to 200)
→ has variant	Mutationother 4 accepted CIViC evidence items	—	—	Malignant Neoplasm,Head and Neck Squamous Cell Carcinoma,Bladder Urothelial Carcinoma	4	Curated	civic	graph →
→ has variant	G13DSNV 3 accepted CIViC evidence items	—	—	Skin Squamous Cell Carcinoma,Malignant Colorectal Neoplasm	3	Curated	civic	graph →
→ has variant	G12VSNV 1 accepted CIViC evidence items	—	—	Malignant Neoplasm	1	Curated	civic	graph →
→ has variant	Q61 1 accepted CIViC evidence items	—	—	Thyroid Gland Follicular Carcinoma	1	Curated	civic	graph →
→ has variant	Q61LSNV 1 accepted CIViC evidence items	—	—	Malignant Neoplasm	1	Curated	civic	graph →
→ has variant	Q61RSNV 1 accepted CIViC evidence items	—	—	Malignant Neoplasm	1	Curated	civic	graph →
→ has variant	G12DSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	G13RSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	G13VSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	N86TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005343.4(HRAS):c.100C>T (p.Pro34Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005343.4(HRAS):c.111+18G>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005343.4(HRAS):c.144_145insC (p.Glu49fs)insertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005343.4(HRAS):c.145G>A (p.Glu49Lys)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005343.4(HRAS):c.146del (p.Glu49fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

HRAS altered in cohorts of …ALTERED_INderived1 of 1
→ altered in cohorts of	Head and Neck Squamous Cell Carcinomasubtype 31 / 515 cases (6.0 %) · ssm · hnsc_tcga_pan_can_atlas_2018 · largest of 3 cohorts	—	—	Head and Neck Squamous Cell Carcinoma	3	Observed	cbioportal	graph →

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Every edge, grouped by relationship

Paths