Variant · Snv

HRAS G13R

CI-VAR-00001637Explore in graph →NP_005334.1:p.Gly13ArgNM_005343.3:c.37G>CClinVar 35554 CIViC 1393 rs104894228

Curated evidence

Evidence by cancer (3 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–3 of 3 evidence items across 3 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Neoplasm1
HRAS G13R	(oncogenic)	Oncogenic	D	Supports Oncogenicity	5	submitted	EID12906 HRAS p.Gly13Arg (NM_005343.4:c.37G>C) causes increased proliferation, experiments were done in triplicates. PMID 22683711 · Groesser et al., 2012 · Open in CIViC	civic
Thyroid Gland Carcinoma1
HRAS G13R	Vemurafenib	Predictive	D	Supports Resistance	—	submitted	EID3853 In an in vitro study, a C643 cell line expressing HRAS G13R demonstrated reduced sensitivity to vemurafenib treatment, compared to BRAF V600E expressing cells (8505C, SWI1736, BHT101 and BCPAP). Sensi… (full text at CIViC) PMID 19880792 · Salerno et al., 2010 · Open in CIViC

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
35554	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts	2	Linear nevus sebaceous syndrome; Nevus sebaceous; Epidermal nevus; NEVUS SPILUS, SOMATIC; SPITZ NEVUS, SOMATIC; Lip and oral cavity carcinoma; Non-immune hydrops fetalis; Costello syndrome; Noonan syndrome and Noonan-related syndrome; cutaneous-skeletal hypophosphatemia syndrome; HRAS-related disorder; Ectomesenchymoma; Alveolar rhabdomyosarcoma; Embryonal rhabdomyosarcoma; Breast phyllodes tumor; HRAS-related disorders