FLT3

fms related receptor tyrosine kinase 3

Identifier: CI-GENE-00002044
Entity page: /gene/FLT3 ↗
Edges: 134

Neighbours: 9 cancers15 variants15 drugs
Drawn: 39 of 39 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

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Edges

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
FLT3 associated with …ASSOCIATED_WITH10 of 10
→ associated with	Acute Myeloid Leukemiahematologic_malignancy 3 source records aggregated	supports	A	Acute Myeloid Leukemia	3	Curated	civic	graph →
→ associated with	Acute Myeloid Leukemiahematologic_malignancy

FLT3 targets …TARGETS15 of 18show all (up to 200)
← targets	Tandutinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Sunitinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Sorafenib Tosylatesmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Sorafenibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Quizartinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Pexidartinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Pacritinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	NVP-AST487small_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Ningetinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Midostaurinsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Linifanibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Lestaurtinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Gilteritinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Foretinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Fedratinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →

FLT3 targets …TARGETS15 of 18show all (up to 200)

← targets

Tandutinibsmall_molecule

—

INHIBITOR

—

Curated

FLT3 has variant …HAS_VARIANTderived15 of 102show all (up to 200)
→ has variant	ITDinsertion 33 accepted CIViC evidence items	—	—	Leukemia,Acute Myeloid Leukemia,Acute Promyelocytic Leukemia	33	Curated	civic	graph →
→ has variant	D835VSNV 8 accepted CIViC evidence items	—	—	Acute Myeloid Leukemia	8	Curated	civic	graph →
→ has variant	D835 6 accepted CIViC evidence items	—	—	Myelodysplastic Syndrome,Acute Myeloid Leukemia	6	Curated	civic	graph →
→ has variant	D835YSNV 6 accepted CIViC evidence items	—	—	Malignant Neoplasm,Acute Myeloid Leukemia	6	Curated	civic	graph →
→ has variant	TKD MUTATION 6 accepted CIViC evidence items	—	—	Acute Myeloid Leukemia	6	Curated	civic	graph →
→ has variant	Y842CSNV 6 accepted CIViC evidence items	—	—	Acute Myeloid Leukemia	6	Curated	civic	graph →
→ has variant	Mutationother 3 accepted CIViC evidence items	—	—	Acute Myeloid Leukemia	3	Curated	civic	graph →
→ has variant	D835HSNV 2 accepted CIViC evidence items	—	—	Acute Myeloid Leukemia	2	Curated	civic	graph →
→ has variant	F691LSNV 2 accepted CIViC evidence items	—	—	Acute Myeloid Leukemia	2	Curated	civic	graph →
→ has variant	Overexpressionexpression 2 accepted CIViC evidence items	—	—	Acute Myeloid Leukemia,Adult B Acute Lymphoblastic Leukemia	2	Curated	civic	graph →
→ has variant	Amplificationamplification 1 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ has variant	D593deldeletion 1 accepted CIViC evidence items	—	—	Acute Myeloid Leukemia	1	Curated	civic	graph →
→ has variant	D835H/YSNV 1 accepted CIViC evidence items	—	—	Acute Myeloid Leukemia	1	Curated	civic	graph →
→ has variant	D835ISNV 1 accepted CIViC evidence items	—	—	Acute Myeloid Leukemia	1	Curated	civic	graph →
→ has variant	I836 1 accepted CIViC evidence items	—	—	Acute Myeloid Leukemia	1	Curated	civic	graph →

FLT3 altered in cohorts of …ALTERED_INderived4 of 4
→ altered in cohorts of	Acute Myeloid Leukemiahematologic_malignancy 278 / 903 cases (31 %) · ssm · aml_ohsu_2022 · largest of 7 cohorts	—	—	Acute Myeloid Leukemia	7	Observed	cbioportal	graph →
→ altered in cohorts of	Skin Basal Cell Carcinoma 58 / 293 cases (20 %) · ssm · bcc_unige_2016	—	—	Skin Basal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 94 / 696 cases (14 %) · ssm · mel_mskimpact_2020	—	—	Cutaneous Melanoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Myelodysplastic Syndromehematologic_malignancy 475 / 4,231 cases (11 %) · ssm · mds_mskcc_2020	—	—	Myelodysplastic Syndrome	1	Observed	cbioportal	graph →

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