FAT3

FAT atypical cadherin 3

Identifier: CI-GENE-00001651
Entity page: /gene/FAT3 ↗
Edges: 30

Neighbours: 23 cancers7 variants
Drawn: 30 of 30 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
FAT3 has variant …HAS_VARIANTderived7 of 7
→ has variant	NM_001367949.2(FAT3):c.10222C>T (p.Arg3408Trp)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001367949.2(FAT3):c.10613G>A (p.Arg3538His)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed

FAT3 altered in cohorts of …ALTERED_INderived23 of 23show fewer
→ altered in cohorts of	Skin Squamous Cell Carcinoma 28 / 39 cases (72 %) · ssm · cscc_hgsc_bcm_2014 · largest of 2 cohorts	—	—	Skin Squamous Cell Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 138 / 469 cases (29 %) · ssm · skcm_tcga_gdc · largest of 6 cohorts	—	—	Cutaneous Melanoma	6	Observed	cbioportal	graph →
→ altered in cohorts of	Melanoma 39 / 144 cases (27 %) · ssm · mel_dfci_2019 · largest of 2 cohorts	—	—	Melanoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Adenocarcinoma 121 / 566 cases (21 %) · ssm · luad_tcga_pan_can_atlas_2018 · largest of 9 cohorts	—	—	Lung Adenocarcinoma	9	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Non-Small Cell Carcinoma 222 / 1,144 cases (19 %) · ssm · nsclc_tcga_broad_2016 · largest of 2 cohorts	—	—	Lung Non-Small Cell Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Carcinoma 99 / 517 cases (19 %) · ssm · ucec_tcga_pan_can_atlas_2018 · largest of 4 cohorts	—	—	Endometrial Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Small Cell Carcinoma 22 / 120 cases (18 %) · ssm · sclc_ucologne_2015	—	—	Lung Small Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Gastroesophageal Junction Adenocarcinoma 88 / 518 cases (17 %) · ssm · stes_tcga_pub	—	—	Gastroesophageal Junction Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Squamous Cell Carcinoma 82 / 484 cases (17 %) · ssm · lusc_tcga_pan_can_atlas_2018 · largest of 5 cohorts	—	—	Lung Squamous Cell Carcinoma	5	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Endometrioid Adenocarcinoma 41 / 247 cases (17 %) · ssm · uec_cptac_gdc	—	—	Endometrial Endometrioid Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Gastric Adenocarcinoma 73 / 478 cases (15 %) · ssm · stad_tcga · largest of 5 cohorts	—	—	Gastric Adenocarcinoma	5	Observed	cbioportal	graph →
→ altered in cohorts of	Colon Adenocarcinoma 63 / 429 cases (15 %) · ssm · coad_tcga_gdc · largest of 4 cohorts	—	—	Colon Adenocarcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Esophageal Adenocarcinoma 25 / 185 cases (14 %) · ssm · esca_tcga · largest of 3 cohorts	—	—	Esophageal Adenocarcinoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Hepatocellular Carcinoma 50 / 494 cases (10 %) · ssm · hcc_clca_2024 · largest of 4 cohorts	—	—	Hepatocellular Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Colorectal Adenocarcinoma 87 / 1,015 cases (8.6 %) · ssm · crc_sysucc_2022 · largest of 4 cohorts	—	—	Colorectal Adenocarcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Head and Neck Squamous Cell Carcinoma 43 / 515 cases (8.3 %) · ssm · hnsc_tcga_pan_can_atlas_2018 · largest of 4 cohorts	—	—	Head and Neck Squamous Cell Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Multiple Myeloma 78 / 961 cases (8.1 %) · ssm · MMRF-COMMPASS	—	—	Multiple Myeloma	1	Observed	gdc	graph →
→ altered in cohorts of	Bladder Urothelial Carcinoma 33 / 474 cases (7.0 %) · ssm · blca_msk_tcga_2020 · largest of 5 cohorts	—	—	Bladder Urothelial Carcinoma	5	Observed	cbioportal	graph →
→ altered in cohorts of	B-Cell Non-Hodgkin Lymphoma 52 / 755 cases (6.9 %) · ssm · mbn_mdacc_2013 · largest of 2 cohorts	—	—	B-Cell Non-Hodgkin Lymphoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Cholangiocarcinoma 27 / 417 cases (6.5 %) · ssm · chol_icgc_2017	—	—	Cholangiocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Prostate Adenocarcinoma 27 / 444 cases (6.1 %) · ssm · prad_su2c_2019	—	—	Prostate Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	High-Grade Serous Ovarian Cancer 23 / 405 cases (5.7 %) · ssm · hgsoc_tcga_gdc	—	—	High-Grade Serous Ovarian Cancer	1	Observed	cbioportal	graph →
→ altered in cohorts of	Diffuse Glioma 23 / 444 cases (5.2 %) · ssm · difg_glass_2019	—	—	Diffuse Glioma	1	Observed	cbioportal	graph →

FAT3 altered in cohorts of …ALTERED_INderived23 of 23show fewer

→ altered in cohorts of

Skin Squamous Cell Carcinoma

28 / 39 cases (72 %) · ssm · cscc_hgsc_bcm_2014 · largest of 2 cohorts

—

Skin Squamous Cell Carcinoma

Observed

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