DNAH5

dynein axonemal heavy chain 5

Identifier: CI-GENE-00043533
Entity page: /gene/DNAH5 ↗
Edges: 56

Neighbours: 24 cancers15 variants
Drawn: 39 of 39 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
DNAH5 has variant …HAS_VARIANTderived15 of 32show all (up to 200)
→ has variant	NM_001369.3(DNAH5):c.10041G>T (p.Met3347Ile)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001369.3(DNAH5):c.10281+118A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0

DNAH5 altered in cohorts of …ALTERED_INderived24 of 24show fewer
→ altered in cohorts of	Cutaneous Melanoma 350 / 470 cases (74 %) · ssm · TCGA-SKCM · largest of 10 cohorts	—	—	Cutaneous Melanoma	10	Observed	gdc	graph →
→ altered in cohorts of	Skin Basal Cell Carcinoma 77 / 126 cases (61 %) · ssm · bcc_unige_2016	—	—	Skin Basal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Melanoma 69 / 144 cases (48 %) · ssm · mel_dfci_2019 · largest of 4 cohorts	—	—	Melanoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Skin Squamous Cell Carcinoma 38 / 83 cases (46 %) · ssm · cscc_ucsf_2021 · largest of 3 cohorts	—	—	Skin Squamous Cell Carcinoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Head and Neck Carcinoma, Other 22 / 108 cases (20 %) · ssm · ohnca_cptac_gdc	—	—	Head and Neck Carcinoma, Other	1	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Carcinoma 100 / 517 cases (19 %) · ssm · ucec_tcga_pan_can_atlas_2018 · largest of 4 cohorts	—	—	Endometrial Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Squamous Cell Carcinoma 93 / 484 cases (19 %) · ssm · lusc_tcga_pan_can_atlas_2018 · largest of 6 cohorts	—	—	Lung Squamous Cell Carcinoma	6	Observed	cbioportal	graph →
→ altered in cohorts of	Gastroesophageal Junction Adenocarcinoma 99 / 518 cases (19 %) · ssm · stes_tcga_pub	—	—	Gastroesophageal Junction Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Renal Cell Carcinoma 30 / 158 cases (19 %) · ssm · rcc_iatlas_immotion150_2018	—	—	Renal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Esophageal Adenocarcinoma 35 / 185 cases (19 %) · ssm · esca_tcga · largest of 3 cohorts	—	—	Esophageal Adenocarcinoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Colon Adenocarcinoma 80 / 429 cases (19 %) · ssm · coad_tcga_gdc · largest of 4 cohorts	—	—	Colon Adenocarcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Endometrioid Adenocarcinoma 42 / 247 cases (17 %) · ssm · uec_cptac_gdc	—	—	Endometrial Endometrioid Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Small Cell Carcinoma 20 / 120 cases (17 %) · ssm · sclc_ucologne_2015	—	—	Lung Small Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Non-Small Cell Carcinoma 181 / 1,144 cases (16 %) · ssm · nsclc_tcga_broad_2016 · largest of 2 cohorts	—	—	Lung Non-Small Cell Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Gastric Adenocarcinoma 73 / 478 cases (15 %) · ssm · stad_tcga · largest of 5 cohorts	—	—	Gastric Adenocarcinoma	5	Observed	cbioportal	graph →
→ altered in cohorts of	Head and Neck Squamous Cell Carcinoma 70 / 515 cases (14 %) · ssm · hnsc_tcga_pan_can_atlas_2018 · largest of 4 cohorts	—	—	Head and Neck Squamous Cell Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Adenocarcinoma 70 / 566 cases (12 %) · ssm · luad_tcga_pan_can_atlas_2018 · largest of 6 cohorts	—	—	Lung Adenocarcinoma	6	Observed	cbioportal	graph →
→ altered in cohorts of	Colorectal Adenocarcinoma 92 / 1,015 cases (9.1 %) · ssm · crc_sysucc_2022 · largest of 5 cohorts	—	—	Colorectal Adenocarcinoma	5	Observed	cbioportal	graph →
→ altered in cohorts of	Bladder Urothelial Carcinoma 41 / 474 cases (8.6 %) · ssm · blca_msk_tcga_2020 · largest of 6 cohorts	—	—	Bladder Urothelial Carcinoma	6	Observed	cbioportal	graph →
→ altered in cohorts of	Diffuse Glioma 49 / 629 cases (7.8 %) · ssm · difg_glass · largest of 4 cohorts	—	—	Diffuse Glioma	4	Observed	cbioportal	graph →
→ altered in cohorts of	B-Cell Non-Hodgkin Lymphoma 23 / 297 cases (7.7 %) · ssm · mbn_sfu_2023	—	—	B-Cell Non-Hodgkin Lymphoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Invasive Breast Carcinoma 167 / 2,433 cases (6.9 %) · ssm · brca_metabric · largest of 3 cohorts	—	—	Invasive Breast Carcinoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Hepatocellular Carcinoma 32 / 494 cases (6.5 %) · ssm · hcc_clca_2024	—	—	Hepatocellular Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Multiple Myeloma 59 / 961 cases (6.1 %) · ssm · MMRF-COMMPASS	—	—	Multiple Myeloma	1	Observed	gdc	graph →

DNAH5 altered in cohorts of …ALTERED_INderived24 of 24show fewer

→ altered in cohorts of

Cutaneous Melanoma

350 / 470 cases (74 %) · ssm · TCGA-SKCM · largest of 10 cohorts

—

Cutaneous Melanoma

Observed

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