CSMD1

CUB and Sushi multiple domains 1

Identifier: CI-GENE-00042336
Entity page: /gene/CSMD1 ↗
Edges: 33

Neighbours: 27 cancers6 variants
Drawn: 33 of 33 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
CSMD1 has variant …HAS_VARIANTderived6 of 6
→ has variant	NM_033225.6(CSMD1):c.1052A>T (p.Asp351Val)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_033225.6(CSMD1):c.1222+7C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed

CSMD1 altered in cohorts of …ALTERED_INderived27 of 27show fewer
→ altered in cohorts of	Skin Squamous Cell Carcinoma 32 / 39 cases (82 %) · ssm · cscc_hgsc_bcm_2014 · largest of 2 cohorts	—	—	Skin Squamous Cell Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Skin Basal Cell Carcinoma 203 / 293 cases (69 %) · ssm · bcc_unige_2016	—	—	Skin Basal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Carcinoma 270 / 559 cases (48 %) · ssm · TCGA-UCEC · largest of 5 cohorts	—	—	Endometrial Carcinoma	5	Observed	gdc	graph →
→ altered in cohorts of	Diffuse Large B-Cell Lymphoma 22 / 50 cases (44 %) · ssm · TCGA-DLBC	—	—	Diffuse Large B-Cell Lymphoma	1	Observed	gdc	graph →
→ altered in cohorts of	Cutaneous Melanoma 156 / 469 cases (33 %) · ssm · skcm_tcga_gdc · largest of 8 cohorts	—	—	Cutaneous Melanoma	8	Observed	cbioportal	graph →
→ altered in cohorts of	Melanoma 47 / 144 cases (33 %) · ssm · mel_dfci_2019 · largest of 4 cohorts	—	—	Melanoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Small Cell Carcinoma 28 / 120 cases (23 %) · ssm · sclc_ucologne_2015	—	—	Lung Small Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Adenocarcinoma 125 / 566 cases (22 %) · ssm · luad_tcga_pan_can_atlas_2018 · largest of 9 cohorts	—	—	Lung Adenocarcinoma	9	Observed	cbioportal	graph →
→ altered in cohorts of	Gastroesophageal Junction Adenocarcinoma 104 / 518 cases (20 %) · ssm · stes_tcga_pub	—	—	Gastroesophageal Junction Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Non-Small Cell Carcinoma 225 / 1,144 cases (20 %) · ssm · nsclc_tcga_broad_2016 · largest of 2 cohorts	—	—	Lung Non-Small Cell Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Renal Cell Carcinoma 28 / 158 cases (18 %) · ssm · rcc_iatlas_immotion150_2018	—	—	Renal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Gastric Adenocarcinoma 84 / 478 cases (18 %) · ssm · stad_tcga · largest of 5 cohorts	—	—	Gastric Adenocarcinoma	5	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Squamous Cell Carcinoma 82 / 484 cases (17 %) · ssm · lusc_tcga_pan_can_atlas_2018 · largest of 4 cohorts	—	—	Lung Squamous Cell Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Colon Adenocarcinoma 67 / 429 cases (16 %) · ssm · coad_tcga_gdc · largest of 2 cohorts	—	—	Colon Adenocarcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Rectal Adenocarcinoma 23 / 155 cases (15 %) · ssm · read_tcga_gdc	—	—	Rectal Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Esophageal Adenocarcinoma 27 / 185 cases (15 %) · ssm · esca_tcga · largest of 4 cohorts	—	—	Esophageal Adenocarcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Endometrioid Adenocarcinoma 30 / 247 cases (12 %) · ssm · uec_cptac_gdc	—	—	Endometrial Endometrioid Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Cervical Squamous Cell Carcinoma 27 / 291 cases (9.3 %) · ssm · cesc_tcga_pan_can_atlas_2018 · largest of 2 cohorts	—	—	Cervical Squamous Cell Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	B-Cell Non-Hodgkin Lymphoma 70 / 755 cases (9.3 %) · ssm · mbn_mdacc_2013	—	—	B-Cell Non-Hodgkin Lymphoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Colorectal Adenocarcinoma 90 / 1,015 cases (8.9 %) · ssm · crc_sysucc_2022 · largest of 5 cohorts	—	—	Colorectal Adenocarcinoma	5	Observed	cbioportal	graph →
→ altered in cohorts of	Hepatocellular Carcinoma 43 / 494 cases (8.7 %) · ssm · hcc_clca_2024 · largest of 6 cohorts	—	—	Hepatocellular Carcinoma	6	Observed	cbioportal	graph →
→ altered in cohorts of	Multiple Myeloma 67 / 961 cases (7.0 %) · ssm · MMRF-COMMPASS	—	—	Multiple Myeloma	1	Observed	gdc	graph →
→ altered in cohorts of	Head and Neck Squamous Cell Carcinoma 35 / 515 cases (6.8 %) · ssm · hnsc_tcga_pan_can_atlas_2018 · largest of 4 cohorts	—	—	Head and Neck Squamous Cell Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Cholangiocarcinoma 24 / 417 cases (5.8 %) · ssm · chol_icgc_2017	—	—	Cholangiocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Bladder Urothelial Carcinoma 27 / 474 cases (5.7 %) · ssm · blca_msk_tcga_2020 · largest of 6 cohorts	—	—	Bladder Urothelial Carcinoma	6	Observed	cbioportal	graph →
→ altered in cohorts of	Invasive Breast Carcinoma 20 / 379 cases (5.3 %) · ssm · brca_mbcproject_2022	—	—	Invasive Breast Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Prostate Adenocarcinoma 23 / 444 cases (5.2 %) · ssm · prad_su2c_2019	—	—	Prostate Adenocarcinoma	1	Observed	cbioportal	graph →

Radial view

Every edge, grouped by relationship

Paths