Tyrosine Kinase Inhibitor

Identifier: CI-DRUG-00000617
Entity page: /drug/tyrosine-kinase-inhibitor ↗
Edges: 25

Neighbours: 10 cancers1 variants10 trials
Drawn: 21 of 21 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Tyrosine Kinase Inhibitor predicts response to …PREDICTS_RESPONSE_TO1 of 1
← predicts response to	ABL1 Fusionfusion	sensitivity	C	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	1	Curated	civic	graph →
Tyrosine Kinase Inhibitor investigated for …INVESTIGATED_FOR1 of 1

Tyrosine Kinase Inhibitor investigated in trials for …INVESTIGATED_IN_TRIALSderived9 of 9
→ investigated in trials for	Lung Non-Small Cell Carcinoma 4 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lung Non-Small Cell Carcinoma	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Chronic Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive 2 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Chronic Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Acute Leukemia of Ambiguous Lineage 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Acute Leukemia of Ambiguous Lineage	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Brain Neoplasm 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Brain Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Chronic Myeloid Leukemia, BCR-ABL1 Positive 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Chronic Myeloid Leukemia, BCR-ABL1 Positive	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Hepatocellular Carcinoma 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Hepatocellular Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	HER2-Positive Breast Carcinoma 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	HER2-Positive Breast Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Leukemia 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Leukemia	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Renal Cell Carcinoma 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Renal Cell Carcinoma	1	Observed	clinicaltrials	graph →

Tyrosine Kinase Inhibitor investigated in trials for …INVESTIGATED_IN_TRIALSderived9 of 9

→ investigated in trials for

Lung Non-Small Cell Carcinoma

4 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Lung Non-Small Cell Carcinoma

Observed

Tyrosine Kinase Inhibitor studied in …STUDIED_INderived10 of 14show all (up to 200)
→ studied in	NCT03817398Phase 2 · active not recruiting Stopping Tyrosine Kinase Inhibitors in Affecting Treatment-Free Remission in Patients With Chronic Phase Chronic Myeloid Leukemia · 14 trials list this drug (5 active)	—	—	Chronic Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive	1	Observed	clinicaltrials	graph →
→ studied in	NCT04318938Phase 2 · completed Advancing Brigatinib Properties in ALK+ NSCLC Patients by Deep Phenotyping · 14 trials list this drug (5 active)	—	—	Lung Non-Small Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT03958565recruiting Response of Bony Metastasis to Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancers With Actionable Driver Mutations. · 14 trials list this drug (5 active)	—	—	Lung Non-Small Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT05236946Phase 3 · recruiting Observation or Upfront Cranial RT in Oncogene Mutated NSCLC With Asymptomatic BM: A Phase III RCT · 14 trials list this drug (5 active)	—	—	not mapped	1	Observed	clinicaltrials	graph →
→ studied in	NCT04440267Phase 2 · recruiting Efficacy of Acute Lymphoblastic Leukemia-Based Therapy in Treating Patients With Acute Leukemia of Ambiguous Lineage · 14 trials list this drug (5 active)	—	—	Acute Leukemia of Ambiguous Lineage	1	Observed	clinicaltrials	graph →
→ studied in	NCT06632106active not recruiting HAIC in Combination with Immune Checkpoint Inhibitors and Tyrosine Kinase Inhibitors for Advanced HCC · 14 trials list this drug (5 active)	—	—	Hepatocellular Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04375150completed Master Protocol to Study Treatment Patterns, Medication Adherence, Health and Economic Outcomes and Unmet Needs in RCC · 14 trials list this drug (5 active)	—	—	Renal Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT02949843Phase 2 · terminated Targeted Therapy in Treating Patients With Incurable Non-Small Cell Lung Cancer With Genetic Mutations · 14 trials list this drug (5 active)	—	—	Lung Non-Small Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04006847Phase 1/Phase 2 · terminated Omega -3 Fatty Acid in Combination With Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia · 14 trials list this drug (5 active)	—	—	Chronic Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive	1	Observed	clinicaltrials	graph →
→ studied in	NCT04760431Phase 2 · unknown TKIs vs. Pertuzumab in HER2+ Breast Cancer Patients With Active Brain Metastases (HER2BRAIN) · 14 trials list this drug (5 active)	—	—	Brain Neoplasm,HER2-Positive Breast Carcinoma	1	Observed	clinicaltrials	graph →

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