Isatuximab

monoclonal antibody

Identifier: CI-DRUG-00000738
Entity page: /drug/isatuximab ↗
Edges: 106

Neighbours: 17 cancers1 genes10 trials8 approvals
Drawn: 36 of 36 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Isatuximab approved for …APPROVED_FOR10 of 8
→ approved for	Multiple Myelomahematologic_malignancy	supports	FDA ORIG	Multiple Myeloma	1	Regulatory	openfda	graph →
→ approved for	Multiple Myelomahematologic_malignancy	supports	EMA indication text

Isatuximab targets …TARGETS1 of 1
→ targets	CD38	—	INHIBITOR	—	1	Curated	chembl	graph →

Isatuximab targets …TARGETS1 of 1

→ targets

CD38

—

INHIBITOR

—

Curated

Isatuximab investigated for …INVESTIGATED_FOR9 of 9
→ investigated for	Neoplasmcancer_family	unknown	4	Neoplasm	1	Curated	chembl	graph →
→ investigated for	Multiple Myelomahematologic_malignancy	unknown	4	Multiple Myeloma	1	Curated	chembl	graph →
→ investigated for	T Acute Lymphoblastic Leukemiahematologic_malignancy	unknown	2	T Acute Lymphoblastic Leukemia	1	Curated	chembl	graph →
→ investigated for	Smoldering Multiple Myelomahematologic_malignancy	unknown	2	Smoldering Multiple Myeloma	1	Curated	chembl	graph →
→ investigated for	Lymphomacancer_family	unknown	2	Lymphoma	1	Curated	chembl	graph →
→ investigated for	Acute Myeloid Leukemiahematologic_malignancy	unknown	2	Acute Myeloid Leukemia	1	Curated	chembl	graph →
→ investigated for	Acute Lymphoblastic Leukemiahematologic_malignancy	unknown	2	Acute Lymphoblastic Leukemia	1	Curated	chembl	graph →
→ investigated for	Colorectal Neoplasmsubtype	unknown	1	Colorectal Neoplasm	1	Curated	chembl	graph →
→ investigated for	Hematopoietic and Lymphoid Cell Neoplasmcancer_family	unknown	1	Hematopoietic and Lymphoid Cell Neoplasm	1	Curated	chembl	graph →

Isatuximab investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 20show all (up to 200)
→ investigated in trials for	Multiple Myelomahematologic_malignancy 53 trials (41 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Multiple Myeloma	53	Observed	clinicaltrials	graph →
→ investigated in trials for	Plasma Cell Neoplasm 3 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Plasma Cell Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Acute Myeloid Leukemiahematologic_malignancy 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Acute Myeloid Leukemia	2	Observed	clinicaltrials	graph →
→ investigated in trials for	AL Amyloidosis 2 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	AL Amyloidosis	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Liquid Tumor 2 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Liquid Tumor	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Lymphomacancer_family 2 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lymphoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Neoplasm 2 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Neoplasmcancer_family 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Non-Hodgkin Lymphoma 2 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Non-Hodgkin Lymphoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Plasma Cell Leukemia 2 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Plasma Cell Leukemia	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Smoldering Multiple Myelomahematologic_malignancy 2 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Smoldering Multiple Myeloma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Acute Lymphoblastic Leukemiahematologic_malignancy 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Acute Lymphoblastic Leukemia	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Adult Hodgkin Lymphoma 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Adult Hodgkin Lymphoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Diffuse Large B-Cell Lymphoma 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Diffuse Large B-Cell Lymphoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Hematopoietic and Lymphoid Cell Neoplasmcancer_family 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Hematopoietic and Lymphoid Cell Neoplasm	1	Observed	clinicaltrials	graph →

Isatuximab studied in …STUDIED_INderived10 of 68show all (up to 200)
→ studied in	NCT07652905Phase 2 · recruiting CM336 Plus Isa-VR in Newly Diagnosed Primary Plasma Cell Leukemia · 68 trials list this drug (50 active)	—	—	Plasma Cell Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT04883242Phase 2 · active not recruiting Isatuximab, Carfilzomib, Pomalidomide, and Dexamethasone for the Treatment of Relapsed or Refractory Multiple Myeloma · 68 trials list this drug (50 active)	—	—	Multiple Myeloma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06832865Phase 2 · recruiting ELISA in Relapsed/Refractory MM · 68 trials list this drug (50 active)	—	—	Multiple Myeloma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06182774Phase 3 · recruiting Fixed Duration vs Continuous Anti-CD38 Antibody Therapy Among Transplant Ineligible Older Adults With Newly-Diagnosed Multiple Myeloma · 68 trials list this drug (50 active)	—	—	Multiple Myeloma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06517017Phase 2 · recruiting Use of Isatuximab, Dexamethasone and Lenalidomide in a Go-Slow Fashion for Ultra-Frail Patients With Multiple Myeloma · 68 trials list this drug (50 active)	—	—	Multiple Myeloma,Plasma Cell Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT07624513Phase 3 · not yet recruiting D2 - Isa-Iber-VD Induction, Followed by Risk & Response Adapted Consolidation & Maintenance, in Transplant-Eligible NDMM · 68 trials list this drug (50 active)	—	—	Multiple Myeloma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07601100Phase 1/Phase 2 · not yet recruiting Isatuximab, Iberdomide, Bortezomib, Dexamethasone in Transplant Ineligible/Deferred Newly Diagnosed Myeloma · 68 trials list this drug (50 active)	—	—	Multiple Myeloma	1	Observed	clinicaltrials	graph →
→ studied in	NCT05405166Phase 3 · active not recruiting SC Versus IV Isatuximab in Combination With Pomalidomide and Dexamethasone in RRMM · 68 trials list this drug (50 active)	—	—	not mapped	1	Observed	clinicaltrials	graph →
→ studied in	NCT05272826Phase 2 · recruiting Study of Iberdomide, Bortezomib, Dexamethasone With Isatuximab Added on Demand for ND-NTE MM Patients · 68 trials list this drug (50 active)	—	—	Multiple Myeloma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07479979Phase 1/Phase 2 · recruiting Study of Selinexor With Carfilzomib, Isatuximab and Dexamethasone for Patients With Relapsed and/or Refractory Multiple Myeloma · 68 trials list this drug (50 active)	—	—	Multiple Myeloma	1	Observed	clinicaltrials	graph →

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