Immune Checkpoint Inhibitor

Identifier: CI-DRUG-00000298
Entity page: /drug/immune-checkpoint-inhibitor ↗
Edges: 65

Neighbours: 23 cancers6 variants10 trials
Drawn: 39 of 39 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Immune Checkpoint Inhibitor predicts response to …PREDICTS_RESPONSE_TO7 of 7
← predicts response to	LRP1B Loss-of-function 2 source records aggregated	sensitivity	B	Lung Adenocarcinoma,Solid Neoplasm	2	Curated	civic	graph →
← predicts response to	CDKN2A Lossdeletion_cna

Immune Checkpoint Inhibitor investigated for …INVESTIGATED_FOR6 of 6
→ investigated for	Lung Adenocarcinomasubtype	supports	B	Lung Adenocarcinoma	1	Curated	civic	graph →
→ investigated for	Bladder Urothelial Carcinomasubtype	supports	B	Bladder Urothelial Carcinoma	1	Curated	civic	graph →
→ investigated for	Solid Neoplasmcancer_family	supports	B	Solid Neoplasm	1	Curated	civic	graph →
→ investigated for	Lung Non-Small Cell Carcinomasubtype	supports	B	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ investigated for	Triple-Negative Breast Carcinomamolecular_subtype	supports	E	Triple-Negative Breast Carcinoma	1	Curated	civic	graph →
→ investigated for	Lung Non-Small Cell Carcinomasubtype	supports	E	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →

Immune Checkpoint Inhibitor investigated for …INVESTIGATED_FOR6 of 6

→ investigated for

Lung Adenocarcinomasubtype

supports

Lung Adenocarcinoma

Curated

Immune Checkpoint Inhibitor investigated in trials for …INVESTIGATED_IN_TRIALSderived20 of 20show fewer
→ investigated in trials for	Lung Non-Small Cell Carcinomasubtype 9 trials (6 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lung Non-Small Cell Carcinoma	9	Observed	clinicaltrials	graph →
→ investigated in trials for	Hepatocellular Carcinoma 4 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Hepatocellular Carcinoma	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Adult Solid Neoplasm 3 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Adult Solid Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Head and Neck Squamous Cell Carcinoma 3 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Head and Neck Squamous Cell Carcinoma	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Melanoma 3 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Melanoma	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Neoplasm 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Solid Neoplasmcancer_family 2 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Solid Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Biliary Tract Carcinoma 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Biliary Tract Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Breast Carcinoma 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Breast Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Breast Neoplasm 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Breast Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Colorectal Carcinoma 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Colorectal Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Hematopoietic and Lymphoid Cell Neoplasm 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Hematopoietic and Lymphoid Cell Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Hodgkin Lymphoma 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Hodgkin Lymphoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Lung Non-Squamous Non-Small Cell Carcinoma 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lung Non-Squamous Non-Small Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Lung Small Cell Carcinoma 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lung Small Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Gastric Neoplasm 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Gastric Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Lung Neoplasm 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Lung Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Solid Neoplasm 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Solid Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Nasopharyngeal Carcinoma 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Nasopharyngeal Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Renal Cell Carcinoma 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Renal Cell Carcinoma	1	Observed	clinicaltrials	graph →

Immune Checkpoint Inhibitor studied in …STUDIED_INderived10 of 32show all (up to 200)
→ studied in	NCT07572864Phase 2 · recruiting Neoadjuvant ICI and Mitochondrial Vaccine for Resectable HNSCC · 32 trials list this drug (18 active)	—	—	Head and Neck Squamous Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07759856Phase 2 · recruiting NK Cells Plus ICI for SCLC Maintenance · 32 trials list this drug (18 active)	—	—	Lung Small Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04913311recruiting Predictive Biomarkers for Pneumonitis After Chemoradiotherapy and Immunotherapy in Patients With Non-small Cell Lung Cancer · 32 trials list this drug (18 active)	—	—	Lung Non-Small Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07405086Phase 4 · recruiting Morning Versus Afternoon Administration of Immunotherapy for the Treatment of Advanced or Metastatic Solid Tumors, The Knight SHIFT Study · 32 trials list this drug (18 active)	—	—	Malignant Solid Neoplasm,Melanoma,Malignant Lung Neoplasm+2	1	Observed	clinicaltrials	graph →
→ studied in	NCT06502691Phase 1/Phase 2 · recruiting [18F]FTT Positron Emission Tomography for the Measurement of PARP Tumor Expression in Patients With Metastatic Breast Cancer · 32 trials list this drug (18 active)	—	—	Breast Neoplasm,Breast Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT05846659Phase 2 · terminated Study of PULSAR-ICI +/- IMSA101 in Patients With Oligoprogressive Solid Tumor Malignancies · 32 trials list this drug (18 active)	—	—	not mapped	1	Observed	clinicaltrials	graph →
→ studied in	NCT05941741Phase 3 · recruiting IC Plus Low-dose Radiation Plus Cadonilimab in LANPC · 32 trials list this drug (18 active)	—	—	Nasopharyngeal Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06819735Phase 1/Phase 2 · recruiting Study of DT-7012 as a Single Agent and in Combination With an Immune Checkpoint Inhibitor in Participants With Advanced Solid Tumors · 32 trials list this drug (18 active)	—	—	Solid Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT05522660Phase 3 · recruiting Immunotherapy or Targeted Therapy With or Without Stereotactic Radiosurgery for Patients With Brain Metastases From Melanoma or Non-small Cell Lung Cancer · 32 trials list this drug (18 active)	—	—	Melanoma,Lung Non-Small Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT03313804Phase 2 · completed Priming Immunotherapy in Advanced Disease With Radiation · 32 trials list this drug (18 active)	—	—	Head and Neck Squamous Cell Carcinoma,Lung Non-Small Cell Carcinoma	1	Observed	clinicaltrials	graph →

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