Busulfan

small molecule

Identifier: CI-DRUG-00000666
Entity page: /drug/busulfan ↗
Edges: 656

Neighbours: 27 cancers10 trials10 approvals
Drawn: 47 of 47 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Busulfan approved for …APPROVED_FOR11 of 10
→ approved for	Myeloid Leukemiahematologic_malignancy	supports	FDA ORIG	Myeloid Leukemia	1	Regulatory	openfda	graph →
→ approved for	Health Canada · CA · 2019Marketed in Canada as PMS-BUSULFAN (DIN 02477343) under ATC L01AB01 BUSULFAN. Indications are not published in the Drug Product Database — see the Health Canada Product Monograph.

Busulfan investigated for …INVESTIGATED_FOR15 of 47show all (up to 200)
→ investigated for	Neoplasmcancer_family	unknown	4	Neoplasm	1	Curated	chembl	graph →
→ investigated for	Leukemiacancer_family	unknown	4	Leukemia	1	Curated	chembl	graph →
→ investigated for	Chronic Myeloid Leukemia, BCR-ABL1 Positivemolecular_subtype	unknown	4	Chronic Myeloid Leukemia, BCR-ABL1 Positive	1	Curated	chembl	graph →
→ investigated for	Essential Thrombocythemiahematologic_malignancy	unknown	3	Essential Thrombocythemia	1	Curated	chembl	graph →
→ investigated for	Ganglioneuroblastomasubtype	unknown	3	Ganglioneuroblastoma	1	Curated	chembl	graph →
→ investigated for	Myelodysplastic Syndromehematologic_malignancy	unknown	3	Myelodysplastic Syndrome	1	Curated	chembl	graph →
→ investigated for	Acute Erythroid Leukemiahematologic_malignancy	unknown	3	Acute Erythroid Leukemia	1	Curated	chembl	graph →
→ investigated for	Chronic Myelomonocytic Leukemiahematologic_malignancy	unknown	3	Chronic Myelomonocytic Leukemia	1	Curated	chembl	graph →
→ investigated for	Acute Basophilic Leukemiahematologic_malignancy	unknown	3	Acute Basophilic Leukemia	1	Curated	chembl	graph →
→ investigated for	Acute Megakaryoblastic Leukemiahematologic_malignancy	unknown	3	Acute Megakaryoblastic Leukemia	1	Curated	chembl	graph →
→ investigated for	Sarcomacancer_family	unknown	3	Sarcoma	1	Curated	chembl	graph →
→ investigated for	Neuroblastomasubtype	unknown	3	Neuroblastoma	1	Curated	chembl	graph →
→ investigated for	Lymphomacancer_family	unknown	3	Lymphoma	1	Curated	chembl	graph →
→ investigated for	Breast Neoplasmcancer_family	unknown	3	Breast Neoplasm	1	Curated	chembl	graph →
→ investigated for	Acute Myelomonocytic Leukemiahematologic_malignancy	unknown	3	Acute Myelomonocytic Leukemia	1	Curated	chembl	graph →

Busulfan investigated for …INVESTIGATED_FOR15 of 47show all (up to 200)

→ investigated for

Neoplasmcancer_family

unknown

Neoplasm

Curated

Busulfan investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 226show all (up to 200)
→ investigated in trials for	Myelodysplastic Syndromehematologic_malignancy 140 trials (25 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Myelodysplastic Syndrome	140	Observed	clinicaltrials	graph →
→ investigated in trials for	Leukemiacancer_family 132 trials (6 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Leukemia	132	Observed	clinicaltrials	graph →
→ investigated in trials for	Lymphomacancer_family 85 trials (6 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lymphoma	85	Observed	clinicaltrials	graph →
→ investigated in trials for	Acute Myeloid Leukemia 79 trials (29 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Acute Myeloid Leukemia	79	Observed	clinicaltrials	graph →
→ investigated in trials for	Multiple Myeloma 41 trials (4 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Multiple Myeloma	41	Observed	clinicaltrials	graph →
→ investigated in trials for	Acute Lymphoblastic Leukemia 40 trials (14 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Acute Lymphoblastic Leukemia	40	Observed	clinicaltrials	graph →
→ investigated in trials for	Myeloproliferative Neoplasm 35 trials (6 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Myeloproliferative Neoplasm	35	Observed	clinicaltrials	graph →
→ investigated in trials for	Myelodysplastic/Myeloproliferative Neoplasm 34 trials (4 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Myelodysplastic/Myeloproliferative Neoplasm	34	Observed	clinicaltrials	graph →
→ investigated in trials for	Non-Hodgkin Lymphoma 25 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Non-Hodgkin Lymphoma	25	Observed	clinicaltrials	graph →
→ investigated in trials for	Adult Acute Myeloid Leukemia 20 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Adult Acute Myeloid Leukemia	20	Observed	clinicaltrials	graph →
→ investigated in trials for	Hodgkin Lymphoma 20 trials (4 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Hodgkin Lymphoma	20	Observed	clinicaltrials	graph →
→ investigated in trials for	Neuroblastomasubtype 20 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Neuroblastoma	20	Observed	clinicaltrials	graph →
→ investigated in trials for	Hematopoietic and Lymphoid Cell Neoplasm 18 trials (8 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Hematopoietic and Lymphoid Cell Neoplasm	18	Observed	clinicaltrials	graph →
→ investigated in trials for	Chronic Lymphocytic Leukemia 17 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Chronic Lymphocytic Leukemia	17	Observed	clinicaltrials	graph →
→ investigated in trials for	Acute Leukemia 15 trials (8 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Acute Leukemia	15	Observed	clinicaltrials	graph →

Busulfan studied in …STUDIED_INderived10 of 373show all (up to 200)
→ studied in	NCT07524530Phase 2 · not yet recruiting Stem Cell Transplantation for Participants With Germline RUNX1 Associated Blood Cancers · 373 trials list this drug (54 active)	—	—	Hematopoietic and Lymphoid Cell Neoplasm,Leukemia,Lymphoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07775313Phase 1/Phase 2 · enrolling by invitation Base-Edited Hematopoietic Stem/Progenitor Cell Gene Therapy for Treatment of CXCR4-WHIM · 373 trials list this drug (54 active)	—	—	not mapped	1	Observed	clinicaltrials	graph →
→ studied in	NCT03779854Phase 2 · active not recruiting Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and Young Adults With Blood Cancers Undergoing Donor Stem Cell Transplant · 373 trials list this drug (54 active)	—	—	Acute Leukemia,Acute Lymphoblastic Leukemia,Burkitt Leukemia+2	1	Observed	clinicaltrials	graph →
→ studied in	NCT05564390Phase 2 · recruiting MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial) · 373 trials list this drug (54 active)	—	—	Myelodysplastic Syndrome,Acute Myeloid Leukemia,Acute Myeloid Leukemia Arising from Previous Myelodysplastic/Myeloproliferative Neoplasm+2	1	Observed	clinicaltrials	graph →
→ studied in	NCT01857934Phase 2 · completed Therapy for Children With Advanced Stage Neuroblastoma · 373 trials list this drug (54 active)	—	—	Neuroblastoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT05327023Phase 1/Phase 2 · recruiting Donor Lymphocyte Infusion After Allogeneic Hematopoietic Cell Transplantation for High-Risk Hematologic Malignancies · 373 trials list this drug (54 active)	—	—	Hematopoietic and Lymphoid Cell Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT06954987Phase 2 · not yet recruiting Venetoclax or Placebo in Combination With Reduced-Intensity Conditioning Hematopoietic Cell (Bone Marrow/Blood Stem Cell) Transplant and as Maintenance Therapy After Transplant in Patients With Acute Myeloid Leukemia (A MyeloMATCH Treatment Trial) · 373 trials list this drug (54 active)	—	—	Acute Myeloid Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT01949129Phase 2/Phase 3 · recruiting Allogeneic Stem Cell Transplantation for Children and Adolescents With Acute Lymphoblastic Leukaemia · 373 trials list this drug (54 active)	—	—	Acute Lymphoblastic Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT07183878NA · recruiting Venetoclax-Enhanced BUCY vs. Standard BUCY Conditioning in High-Risk AML and MDS Patients Undergoing Allo-HSCT (Ven-BUCY Study) · 373 trials list this drug (54 active)	—	—	Myelodysplastic Syndrome,Acute Myeloid Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT01961063Phase 1 · active not recruiting Gene Therapy After Frontline Chemotherapy in Treating Patients With AIDS-Related Non-Hodgkin Lymphoma · 373 trials list this drug (54 active)	—	—	AIDS-Related Non-Hodgkin Lymphoma,AIDS-Related Primary Effusion Lymphoma,AIDS-Related Plasmablastic Lymphoma	1	Observed	clinicaltrials	graph →

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