Amrubicin

small molecule

Identifier: CI-DRUG-00000056
Entity page: /drug/amrubicin ↗
Edges: 44

Neighbours: 15 cancers1 genes2 variants10 trials
Drawn: 28 of 28 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Amrubicin predicts response to …PREDICTS_RESPONSE_TO2 of 2
← predicts response to	NQO1 P187SSNV	sensitivity	D	Malignant Lung Neoplasm	1	Curated	civic	graph →
← predicts response to	NQO1 EXPRESSIONexpression	resistance	D

Amrubicin targets …TARGETS1 of 1
→ targets	TOP2A	—	INHIBITOR	—	1	Curated	chembl	graph →

Amrubicin targets …TARGETS1 of 1

→ targets

TOP2A

—

INHIBITOR

—

Curated

Amrubicin investigated for …INVESTIGATED_FOR9 of 9
→ investigated for	Lung Neoplasmcancer_family	unknown	3	Lung Neoplasm	1	Curated	chembl	graph →
→ investigated for	Lung Small Cell Carcinomasubtype	unknown	3	Lung Small Cell Carcinoma	1	Curated	chembl	graph →
→ investigated for	Neoplasmcancer_family	unknown	3	Neoplasm	1	Curated	chembl	graph →
→ investigated for	Malignant Lung Neoplasmcancer 2 source records aggregated	supports	D	Malignant Lung Neoplasm	2	Curated	civic	graph →
→ investigated for	Breast Neoplasmcancer_family	unknown	2	Breast Neoplasm	1	Curated	chembl	graph →
→ investigated for	Thymomasubtype	unknown	2	Thymoma	1	Curated	chembl	graph →
→ investigated for	Bladder Neoplasmsubtype	unknown	2	Bladder Neoplasm	1	Curated	chembl	graph →
→ investigated for	Sarcomacancer_family	unknown	2	Sarcoma	1	Curated	chembl	graph →
→ investigated for	Multiple Myelomahematologic_malignancy	unknown	1	Multiple Myeloma	1	Curated	chembl	graph →

Amrubicin investigated in trials for …INVESTIGATED_IN_TRIALSderived10 of 10
→ investigated in trials for	Lung Small Cell Carcinomasubtype 11 trials (4 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lung Small Cell Carcinoma	11	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Lung Neoplasmcancer 4 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Lung Neoplasm	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Breast Neoplasm 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Breast Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Bladder Neoplasm 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Bladder Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Thymus Neoplasm 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Thymus Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Multiple Myelomahematologic_malignancy 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Multiple Myeloma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Soft Tissue Sarcoma 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Soft Tissue Sarcoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Solid Neoplasm 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Solid Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Thymomasubtype 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Thymoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Thymus Carcinoma 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Thymus Carcinoma	1	Observed	clinicaltrials	graph →

Amrubicin studied in …STUDIED_INderived10 of 22show all (up to 200)
→ studied in	NCT07365241Phase 3 · recruiting A Study to Evaluate Adverse Events and Change in Disease Activity of Intravenous ABBV-706 Versus Standard of Care in Adult Participants With Relapsed/Refractory Small Cell Lung Cancer · 22 trials list this drug (4 active)	—	—	Lung Small Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06801834Phase 3 · recruiting Study of Sacituzumab Govitecan Versus Standard of Care in Participants With Previously Treated Extensive Stage Small Cell Lung Cancer · 22 trials list this drug (4 active)	—	—	Lung Small Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06203210Phase 3 · recruiting A Study of Ifinatamab Deruxtecan Versus Treatment of Physician's Choice in Subjects With Relapsed Small Cell Lung Cancer · 22 trials list this drug (4 active)	—	—	Lung Small Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT05740566Phase 3 · active not recruiting Study Comparing Tarlatamab With Standard of Care Chemotherapy in Relapsed Small Cell Lung Cancer · 22 trials list this drug (4 active)	—	—	Lung Small Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT01904253Phase 2 · terminated A Phase 2 Study Comparing TAS-102 Versus Topotecan or Amrubicin to Treat Small Cell Lung Cancer Following Platinum-Based Chemotherapy · 22 trials list this drug (4 active)	—	—	Lung Small Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT02481830Phase 3 · completed Effectiveness Study of Nivolumab Compared to Chemotherapy in Patients With Relapsed Small-cell Lung Cancer · 22 trials list this drug (4 active)	—	—	Malignant Lung Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT01033032Phase 1/Phase 2 · completed Trial of Amrubicin as Treatment for Patients With HER2-Negative Metastatic Breast Cancer · 22 trials list this drug (4 active)	—	—	Malignant Breast Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT00286169Phase 3 · terminated Amrubicin Study for Elderly Patients With Extensive-disease Small-cell Lung Cancer (ED-SCLC) · 22 trials list this drug (4 active)	—	—	Lung Small Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT00388960Phase 2 · completed Study of Amrubicin With or Without Cisplatin Versus Etoposide-cisplatin for Extensive Stage Small Cell Lung Cancer · 22 trials list this drug (4 active)	—	—	Lung Small Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT00547651Phase 3 · completed AMR PH GL 2007 CL001 Phase 3 Trial in Patients With Small Cell Lung Cancer After Failure of First-Line Chemotherapy · 22 trials list this drug (4 active)	—	—	Lung Small Cell Carcinoma	1	Observed	clinicaltrials	graph →

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