| Adavosertib studied in …STUDIED_INderived47 of 47show fewer |
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| → studied in | NCT02465060Phase 2 · active not recruiting Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial) · 47 trials list this drug (12 active) | — | — | Hematopoietic and Lymphoid Cell Neoplasm,Lymphoma,Malignant Solid Neoplasm+2 | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT03668340Phase 2 · active not recruiting AZD1775 in Women With Recurrent or Persistent Uterine Serous Carcinoma or Uterine Carcinosarcoma · 47 trials list this drug (12 active) | — | — | Malignant Uterine Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02101775Phase 2 · active not recruiting Gemcitabine Hydrochloride With or Without WEE1 Inhibitor MK-1775 in Treating Patients With Recurrent Ovarian, Primary Peritoneal, or Fallopian Tube Cancer · 47 trials list this drug (12 active) | — | — | Ovarian Brenner Tumor,Primary Peritoneal Carcinoma,Ovarian Carcinoma+2 | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT03284385Phase 2 · active not recruiting Testing AZD1775 in Advanced Solid Tumors That Have a Mutation Called SETD2 · 47 trials list this drug (12 active) | — | — | Malignant Solid Neoplasm,Clear Cell Renal Cell Carcinoma,Renal Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT04460937Phase 1 · active not recruiting Testing the Addition of an Anti-cancer Drug, Adavosertib, to Radiation Therapy for Patients With Incurable Esophageal and Gastroesophageal Junction Cancers · 47 trials list this drug (12 active) | — | — | Esophageal Carcinoma,Esophageal Squamous Cell Carcinoma,Esophageal Adenocarcinoma+2 | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT04439227Phase 2 · active not recruiting Testing AZD1775 as a Potential Targeted Treatment in Cancers With BRCA Genetic Changes (MATCH-Subprotocol Z1I) · 47 trials list this drug (12 active) | — | — | Hematopoietic and Lymphoid Cell Neoplasm,Lymphoma,Malignant Solid Neoplasm+1 | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT03579316Phase 2 · active not recruiting Adavosertib With or Without Olaparib in Treating Patients With Recurrent Ovarian, Primary Peritoneal, or Fallopian Tube Cancer · 47 trials list this drug (12 active) | — | — | Primary Peritoneal Carcinoma,Ovarian Carcinoma,Fallopian Tube Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02813135Phase 1/Phase 2 · recruiting European Proof-of-Concept Therapeutic Stratification Trial of Molecular Anomalies in Relapsed or Refractory Tumors · 47 trials list this drug (12 active) | — | — | Childhood Malignant Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT04197713Phase 1 · active not recruiting Testing the Sequential Combination of the Anti-cancer Drugs Olaparib Followed by Adavosertib (AZD1775) in Patients With Advanced Solid Tumors With Selected Mutations and PARP Resistance, STAR Study · 47 trials list this drug (12 active) | — | — | Malignant Solid Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02659241early Phase 1 · active not recruiting Adavosertib Before Surgery in Treating Patients With Advanced High Grade Ovarian, Fallopian Tube, or Primary Peritoneal Cancer · 47 trials list this drug (12 active) | — | — | Primary Peritoneal Carcinoma,Carcinomatosis,Malignant Fallopian Tube Neoplasm+2 | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02617277Phase 1 · completed Safety, Tolerability and Pharmacokinetics of AZD1775 (Adavosertib) Plus MEDI4736 (Durvalumab) in Patients With Advanced Solid Tumours · 47 trials list this drug (12 active) | — | — | Solid Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02513563Phase 2 · completed AZD1775 Plus Carboplatin-Paclitaxel in Squamous Cell Lung Cancer · 47 trials list this drug (12 active) | — | — | Malignant Lung Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02381548Phase 1 · terminated Phase I Trial of AZD1775 and Belinostat in Treating Patients With Relapsed or Refractory Myeloid Malignancies or Untreated Acute Myeloid Leukemia · 47 trials list this drug (12 active) | — | — | Myelodysplastic Syndrome,Secondary Acute Myeloid Leukemia,Acute Myeloid Leukemia+2 | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02546661Phase 1 · active not recruiting Open-Label, Randomised, Multi-Drug, Biomarker-Directed, Phase 1b Study in Pts w/ Muscle Invasive Bladder Cancer · 47 trials list this drug (12 active) | — | — | not mapped | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT03385655Phase 2 · active not recruiting Prostate Cancer Biomarker Enrichment and Treatment Selection · 47 trials list this drug (12 active) | — | — | Malignant Prostate Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01849146Phase 1 · completed Adavosertib, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed or Recurrent Glioblastoma · 47 trials list this drug (12 active) | — | — | Glioblastoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT03028766Phase 1 · completed WEE1 Inhibitor with Cisplatin and Radiotherapy: a Trial in Head and Neck Cancer · 47 trials list this drug (12 active) | — | — | Malignant Laryngeal Neoplasm,Oral Cavity Squamous Cell Carcinoma,Hypopharyngeal Squamous Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT03345784Phase 1 · terminated Testing AZD1775 inC Combination With Radiotherapy and Chemotherapy in Cervical, Upper Vaginal and Uterine Cancers · 47 trials list this drug (12 active) | — | — | Endometrioid Adenocarcinoma,Malignant Female Reproductive System Neoplasm,Cervical Carcinoma+2 | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01922076Phase 1 · completed Adavosertib and Local Radiation Therapy in Treating Children With Newly Diagnosed Diffuse Intrinsic Pontine Gliomas · 47 trials list this drug (12 active) | — | — | Anaplastic Astrocytoma,Anaplastic Oligoastrocytoma,Glioblastoma+2 | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT03253679Phase 2 · completed AZD1775 in Treating Patients With Advanced Refractory Solid Tumors With CCNE1 Amplification · 47 trials list this drug (12 active) | — | — | Malignant Solid Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02272790Phase 2 · completed Adavosertib Plus Chemotherapy in Platinum-Resistant Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer · 47 trials list this drug (12 active) | — | — | not mapped | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01827384Phase 2 · completed MPACT Study to Compare Effects of Targeted Drugs on Tumor Gene Variations · 47 trials list this drug (12 active) | — | — | Malignant Solid Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02095132Phase 1/Phase 2 · completed Adavosertib and Irinotecan Hydrochloride in Treating Younger Patients With Relapsed or Refractory Solid Tumors · 47 trials list this drug (12 active) | — | — | Central Nervous System Embryonal Tumor,Malignant Solid Neoplasm,Central Nervous System Embryonal Tumor with Rhabdoid Features+2 | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT00648648Phase 1 · completed A Dose Escalation Study of Adavosertib (MK-1775) in Combination With Either Gemcitabine, Cisplatin, or Carboplatin in Adults With Advanced Solid Tumors (MK-1775-001) · 47 trials list this drug (12 active) | — | — | Solid Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01047007Phase 1 · terminated A Dose Escalation Study of Adavosertib(MK1775) in Combination With 5-FU or 5-FU/CDDP in Patients With Advanced Solid Tumor (1775-005 · 47 trials list this drug (12 active) | — | — | Solid Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01357161Phase 2 · completed A Study of Adavosertib (MK-1775) in Combination With Paclitaxel and Carboplatin Versus Paclitaxel and Carboplatin Alone for Participants With Platinum-Sensitive Ovarian Tumors With the P53 Gene Mutation (MK-1775-004) · 47 trials list this drug (12 active) | — | — | Malignant Ovarian Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01076400Phase 1/Phase 2 · terminated A Study of Adavosertib (MK-1775) in Combination With Topotecan/Cisplatin in Participants With Cervical Cancer (MK-1775-008) · 47 trials list this drug (12 active) | — | — | Malignant Cervical Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT04590248Phase 2 · completed A Study of Adavosertib as Treatment for Uterine Serous Carcinoma · 47 trials list this drug (12 active) | — | — | Endometrial Serous Adenocarcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02482311Phase 1 · completed Safety, Tolerance, PK, and Anti-tumour Activity of AZD1775 Monotherapy in Patients With Advanced Solid Tumours · 47 trials list this drug (12 active) | — | — | Malignant Ovarian Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02610075Phase 1 · completed Phase Ib Study to Determine MTD of AZD1775 Monotherapy in Patients With Locally Advanced or Metastatic Solid Tumours. · 47 trials list this drug (12 active) | — | — | Solid Neoplasm,Malignant Ovarian Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02194829Phase 1/Phase 2 · completed Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Gemcitabine Hydrochloride With or Without WEE1 Inhibitor AZD1775 in Treating Patients With Previously Untreated Pancreatic Cancer That Is Metastatic or Cannot Be Removed by Surgery · 47 trials list this drug (12 active) | — | — | Pancreatic Carcinoma,Pancreatic Adenocarcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02576444Phase 2 · terminated OLAParib COmbinations · 47 trials list this drug (12 active) | — | — | Malignant Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT04959266Phase 1 · terminated A Study to Assess the Effects of Itraconazole, Rifampicin, and Omeprazole on Pharmacokinetics of Adavosertib · 47 trials list this drug (12 active) | — | — | Solid Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT05008913Phase 1 · terminated Human Absorption, Distribution, Metabolism, and Excretion Study of [14C]Adavosertib · 47 trials list this drug (12 active) | — | — | Solid Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT04949425Phase 1 · terminated A Study to Assess the Safety and Tolerability of Adavosertib for Patients With Advanced Solid Tumours · 47 trials list this drug (12 active) | — | — | Solid Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT04462952Phase 1 · completed Study of Adavosertib(AZD1775) in Japanese Patients With Advanced Solid Tumours · 47 trials list this drug (12 active) | — | — | Solid Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT05212025Phase 2 · withdrawn Adavosertib and Gemcitabine in Advanced Pancreatic · 47 trials list this drug (12 active) | — | — | Malignant Pancreatic Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT03012477Phase 2 · completed CISPLATIN + AZD-1775 In Breast Cancer · 47 trials list this drug (12 active) | — | — | not mapped | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02585973Phase 1 · completed Dose-escalating AZD1775 + Concurrent Radiation + Cisplatin for Intermediate/High Risk HNSCC · 47 trials list this drug (12 active) | — | — | Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02593019Phase 2 · completed Phase II, Single-arm Study of AZD1775 Monotherapy in Relapsed Small Cell Lung Cancer Patients · 47 trials list this drug (12 active) | — | — | Lung Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02207010early Phase 1 · completed A Phase 0 Study of AZD1775 in Recurrent GBM Patients · 47 trials list this drug (12 active) | — | — | Glioblastoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02906059Phase 1 · completed Study of Irinotecan and AZD1775, a Selective Wee 1 Inhibitor, in RAS or BRAF Mutated, Second-line Metastatic Colorectal Cancer · 47 trials list this drug (12 active) | — | — | Malignant Colorectal Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02511795Phase 1 · completed AZD1775 Combined With Olaparib in Patients With Refractory Solid Tumors · 47 trials list this drug (12 active) | — | — | Solid Neoplasm,Lung Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02341456Phase 1 · completed Phase Ib Study AZD1775 in Combination With Carboplatin and Paclitaxel in Adult Asian Patients With Solid Tumours · 47 trials list this drug (12 active) | — | — | Solid Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02688907Phase 2 · terminated Phase II, Single-arm Study of AZD1775 Monotherapy in Relapsed Small Cell Lung Cancer Patients With MYC Family Amplification or CDKN2A Mutation Combined With TP53 Mutation · 47 trials list this drug (12 active) | — | — | Lung Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02087241Phase 2 · terminated Ph II Trial of Carboplatin and Pemetrexed With or Without AZD1775 for Untreated Lung Cancer · 47 trials list this drug (12 active) | — | — | Lung Non-Squamous Non-Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02087176Phase 2 · terminated A Placebo Controlled Study Comparing AZD1775+ Docetaxel Versus Placebo+Docetaxel to Treat Lung Cancer · 47 trials list this drug (12 active) | — | — | Lung Non-Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |