Gene

WEE1

WEE1 G2 checkpoint kinase

Explore in graph →CI-GENE-00038840HGNC:12761 ENSG00000166483 NCBI 7465 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (6)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–6 of 6 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
WEE1 Mutation1
(oncogenic)	Diffuse Large B-Cell LymphomaCURATED_BROADER	Oncogenic	E	Supports Oncogenicity	3	submitted

Cohorts

Alteration frequency by cohort (1)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved1 cohort row · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Triple-Negative Breast Cancer (FUSCC, Cell Research 2020) brca_fuscc_2020	Invasive Breast Carcinoma	Ssm	2

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

WEE1 kinase polymorphism as a predictive biomarker for efficacy of platinum-gemcitabine doublet chemotherapy in advanced non-small cell lung cancer patients.
· Sci Rep · 2015 · PMID 26057002 · validated civic_curation pubmed

WEE1 Overexpression4
Adavosertib	Diffuse Midline Glioma, H3 K27-Altered	Predictive	D	Supports Sensitivity Response	4	submitted	EID7242 Significant WEE1 protein overexpression was detected by IHC in VUMC-DIPG-1 tissue isolated from a patient's frontal lobe. Significant WEE1 protein levels were also found in E98-FM glioma cells. An i… (full text at CIViC) PMID 23270927 · Caretti et al., 2013 · Open in CIViC	civic
〃	Diffuse Midline Glioma, H3 K27-Altered	Predictive	D	Supports Sensitivity Response	3	submitted	EID7243 Two mouse xenograft models were used: one of tumor cells from a genetically engineered mouse with a BRAF V600E mutation, and the other using a patient's DIPG cells (SF8628). SF8628 was found to have … (full text at CIViC) PMID 24305702 · Mueller et al., 2014 · Open in CIViC	civic
〃	Esophageal Squamous Cell CarcinomaALIAS	Predictive	D	Supports Sensitivity Response	3	submitted	EID9232 Within a preclinical study the inhibitory effects of AZD1775 in esophageal squamous cell carcinoma (ESCC) was demonstrated in both in vitro and in-vivo samples that predominantly displayed high expres… (full text at CIViC) PMID 31427973 · Bi et al., 2019 · Open in CIViC	civic
〃	Acute Lymphoblastic Leukemia	Predictive	D	Does Not Support Sensitivity Response	2	submitted	EID9231 Through a preclinical trial WEE1 expression evaluated in acute lymphoblastic leukemia cell lines (ALL) shows exceptionally high expression in samples (n=58, 44 diagnosis samples and 14 unpaired relaps… (full text at CIViC) PMID 30068368 · Ghelli Luserna Di Rorà et al., 2018 · Open in CIViC	civic

WEE1 Overexpression4

Adavosertib

Diffuse Midline Glioma, H3 K27-Altered

Predictive

Supports Sensitivity Response

submitted

EID7242

Significant WEE1 protein overexpression was detected by IHC in VUMC-DIPG-1 tissue isolated from a patient's frontal lobe. Significant WEE1 protein levels were also found in E98-FM glioma cells. An i… (full text at CIViC)

PMID 23270927 · Caretti et al., 2013 · Open in CIViC

civic

〃

Diffuse Midline Glioma, H3 K27-Altered

Predictive

Supports Sensitivity Response

submitted

EID7243

Two mouse xenograft models were used: one of tumor cells from a genetically engineered mouse with a BRAF V600E mutation, and the other using a patient's DIPG cells (SF8628). SF8628 was found to have … (full text at CIViC)

PMID 24305702 · Mueller et al., 2014 · Open in CIViC

civic

〃

Esophageal Squamous Cell CarcinomaALIAS

Predictive

Supports Sensitivity Response

submitted

EID9232

Within a preclinical study the inhibitory effects of AZD1775 in esophageal squamous cell carcinoma (ESCC) was demonstrated in both in vitro and in-vivo samples that predominantly displayed high expres… (full text at CIViC)

PMID 31427973 · Bi et al., 2019 · Open in CIViC

civic

〃

Acute Lymphoblastic Leukemia

Predictive

Does Not Support Sensitivity Response

submitted

EID9231

Through a preclinical trial WEE1 expression evaluated in acute lymphoblastic leukemia cell lines (ALL) shows exceptionally high expression in samples (n=58, 44 diagnosis samples and 14 unpaired relaps… (full text at CIViC)

PMID 30068368 · Ghelli Luserna Di Rorà et al., 2018 · Open in CIViC

civic

WEE1 RS39103841
Gemcitabine + Platinum CompoundCombination	Lung Non-Small Cell CarcinomaCURATED_BROADER	Predictive	B	Supports Sensitivity Response	3	accepted	EID814 The presence of the WEE1 polymorphism rs3910384 correlated with OS and PFS of NSCLC patients treated with platinum-based chemotherapy. Especially the combination of two DNA-damaging agents was associa… (full text at CIViC) PMID 26057002 · Liu et al., 2015 · Open in CIViC	civic

WEE1 RS39103841

Gemcitabine + Platinum CompoundCombination

Lung Non-Small Cell CarcinomaCURATED_BROADER

Predictive

Supports Sensitivity Response

accepted

EID814

The presence of the WEE1 polymorphism rs3910384 correlated with OS and PFS of NSCLC patients treated with platinum-based chemotherapy. Especially the combination of two DNA-damaging agents was associa… (full text at CIViC)

PMID 26057002 · Liu et al., 2015 · Open in CIViC

civic