Soft Tissue Sarcoma

subtype

Identifier: CI-CAN-00001533
Entity page: /cancer/soft-tissue-sarcoma ↗
Edges: 1,569

Neighbours: 2 genes23 drugs10 trials
Drawn: 35 of 35 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Soft Tissue Sarcoma approved for …APPROVED_FOR14 of 11
← approved for	Pazopanibsmall_molecule	supports	FDA ORIG	Soft Tissue Sarcoma	1	Regulatory	openfda	graph →
← approved for	Trabectedinsmall_molecule 2 source records aggregated	supports	EMA indication text

Soft Tissue Sarcoma altered in cohorts of …ALTERED_INderived2 of 2
← altered in cohorts of	TP53 40 / 108 cases (37 %) · ssm · usarc_msk_2020	—	—	Uterine Corpus Sarcoma	1	Observed	cbioportal	graph →
← altered in cohorts of	ATRX 25 / 108 cases (23 %) · ssm · usarc_msk_2020	—	—	Uterine Corpus Sarcoma	1	Observed	cbioportal	graph →

Soft Tissue Sarcoma altered in cohorts of …ALTERED_INderived2 of 2

← altered in cohorts of

TP53

40 / 108 cases (37 %) · ssm · usarc_msk_2020

—

Uterine Corpus Sarcoma

Observed

Soft Tissue Sarcoma investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 173show all (up to 200)
→ investigated in trials for	Doxorubicinsmall molecule 83 trials (19 active) · roll-up of the cancer and its descendants	—	—	Soft Tissue Sarcoma	83	Observed	clinicaltrials	graph →
→ investigated in trials for	Cyclophosphamidesmall molecule 39 trials (15 active) · roll-up of the cancer and its descendants	—	—	Soft Tissue Sarcoma	39	Observed	clinicaltrials	graph →
→ investigated in trials for	Gemcitabinesmall molecule 34 trials (6 active) · roll-up of the cancer and its descendants	—	—	Soft Tissue Sarcoma	34	Observed	clinicaltrials	graph →
→ investigated in trials for	Ifosfamidesmall molecule 29 trials (6 active) · roll-up of the cancer and its descendants	—	—	Soft Tissue Sarcoma	29	Observed	clinicaltrials	graph →
→ investigated in trials for	Nivolumabmonoclonal antibody 29 trials (15 active) · roll-up of the cancer and its descendants	—	—	Soft Tissue Sarcoma	29	Observed	clinicaltrials	graph →
→ investigated in trials for	Pazopanibsmall_molecule 29 trials (4 active) · roll-up of the cancer and its descendants	—	—	Soft Tissue Sarcoma	29	Observed	clinicaltrials	graph →
→ investigated in trials for	Pembrolizumabmonoclonal antibody 28 trials (15 active) · roll-up of the cancer and its descendants	—	—	Soft Tissue Sarcoma	28	Observed	clinicaltrials	graph →
→ investigated in trials for	Docetaxelsmall molecule 20 trials (2 active) · roll-up of the cancer and its descendants	—	—	Soft Tissue Sarcoma	20	Observed	clinicaltrials	graph →
→ investigated in trials for	Trabectedinsmall_molecule 20 trials (7 active) · roll-up of the cancer and its descendants	—	—	Soft Tissue Sarcoma	20	Observed	clinicaltrials	graph →
→ investigated in trials for	Ipilimumabmonoclonal antibody 19 trials (8 active) · roll-up of the cancer and its descendants	—	—	Soft Tissue Sarcoma	19	Observed	clinicaltrials	graph →
→ investigated in trials for	Vincristinesmall molecule 19 trials (2 active) · roll-up of the cancer and its descendants	—	—	Soft Tissue Sarcoma	19	Observed	clinicaltrials	graph →
→ investigated in trials for	Bevacizumabmonoclonal antibody 16 trials (3 active) · roll-up of the cancer and its descendants	—	—	Soft Tissue Sarcoma	16	Observed	clinicaltrials	graph →
→ investigated in trials for	Etoposidesmall molecule 15 trials (1 active) · roll-up of the cancer and its descendants	—	—	Soft Tissue Sarcoma	15	Observed	clinicaltrials	graph →
→ investigated in trials for	Carboplatinsmall molecule 14 trials (1 active) · roll-up of the cancer and its descendants	—	—	Soft Tissue Sarcoma	14	Observed	clinicaltrials	graph →
→ investigated in trials for	Filgrastimother 14 trials (3 active) · roll-up of the cancer and its descendants	—	—	Soft Tissue Sarcoma	14	Observed	clinicaltrials	graph →

Soft Tissue Sarcoma studied in …STUDIED_INderived10 of 1,383show all (up to 200)
→ studied in	NCT00006518recruiting Specimen Collections From Participants With HIV Infection, KSHV Infection, Viral-Related Pre-malignant Lesions and Cancer · condition mapped ALIAS · 1,383 trials mapped (403 active)	—	—	Kaposi Sarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT03300830recruiting Molecular Characterization of Viral-associated Tumors, Tumors Occurring in the Setting of HIV or Other Immune Disorders and Castleman Disease · condition mapped ALIAS · 1,383 trials mapped (403 active)	—	—	Kaposi Sarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04577755Phase 2 · active not recruiting Pomalidomide Treatment in Patients With Kaposi Sarcoma · condition mapped ONTOLOGY_EXACT · 1,383 trials mapped (403 active)	—	—	Skin Kaposi Sarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07174427Phase 3 · recruiting Multi-center Study of TBI-1301 (INN: Mipetresgene Autoleucel; Mip-cel) in Patients With NY-ESO-1 Positive Synovial Sarcoma · condition mapped ONTOLOGY_EXACT · 1,383 trials mapped (403 active)	—	—	Synovial Sarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT02923778Phase 2 · active not recruiting Talimogene Laherparepvec and Radiation Therapy in Treating Patients With Newly Diagnosed Soft Tissue Sarcoma That Can Be Removed by Surgery · condition mapped ONTOLOGY_EXACT · 1,383 trials mapped (403 active)	—	—	Soft Tissue Sarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06308419Phase 1 · active not recruiting A Phase I Trial of Combination Gemcitabine and Nab-Sirolimus in Advanced Leiomyosarcomas or Advanced Soft-Tissue Sarcomas With TSC2 or TSC1 Loss-of-function Mutations or Deletions · condition mapped ONTOLOGY_EXACT · 1,383 trials mapped (403 active)	—	—	Soft Tissue Sarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07508358Phase 1 · not yet recruiting Vaginal Sildenafil for Primary Dysmenorrhea · condition mapped ALIAS · 1,383 trials mapped (403 active)	—	—	Uterine Corpus Leiomyoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07686367Phase 2 · not yet recruiting Testing the Anti-Cancer Drug, Brenetafusp (IMCF106C), in Rare Cancers · condition mapped CURATED_BROADER · 1,383 trials mapped (403 active)	—	—	Synovial Sarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07842276Phase 2 · not yet recruiting Utidelone Capsules Combined With Doxorubicin for Advanced Soft Tissue Sarcoma · condition mapped ONTOLOGY_EXACT · 1,383 trials mapped (403 active)	—	—	Soft Tissue Sarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04145518Phase 4 · completed Mechanistic Characterization of Uterine Pain · condition mapped ALIAS · 1,383 trials mapped (403 active)	—	—	Uterine Corpus Leiomyoma	1	Observed	clinicaltrials	graph →

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