Gene

NR4A3

nuclear receptor subfamily 4 group A member 3

Explore in graph →CI-GENE-00017207HGNC:7982 ENSG00000119508 NCBI 8013 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (8)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–8 of 8 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
NR4A3 Fusion2
Pazopanib	Extraskeletal Myxoid Chondrosarcoma	Predictive	B	Supports Sensitivity Response	3	submitted	EID9819 In this single-arm, open-label phase 2 trial, extraskeletal myxoid chondrosarcoma patients treated with pazopanib were reported and 22/23 patients (one patient died before the primary analysis) were e… (full text at CIViC) PMID 31331701 · Stacchiotti et al., 2019 · Open in CIViC	civic
Sunitinib	Extraskeletal Myxoid Chondrosarcoma	Predictive	B	Supports Sensitivity Response	3	submitted	EID6378 his report confirms the therapeutic activity of sunitinib in extraskeletal myxoid chondrosarcoma. Genotype/phenotype analyses support a correlation between response and EWSR1-NR4A3 fusion. PMID 24703573 · Stacchiotti et al., 2014 · Open in CIViC

Cohorts

Alteration frequency by cohort (1)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved1 cohort row · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Prostate Adenocarcinoma (MSK, Cancer Cell 2010) prad_mskcc	Prostate Adenocarcinoma	Ssm	3	106

Literature

Linked publications (6)

25 per page, newest first.

pubmedPublishedShowing 1–6 of 6 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Enhancer hijacking activates oncogenic transcription factor NR4A3 in acinic cell carcinomas of the salivary glands.
· Nat Commun · 2019 · PMID 30664630 · validated civic_curation pubmed
A minority of cases of acinic cell carcinoma of the salivary glands are driven by an NR4A2 rearrangement: the diagnostic utility of the assessment of NR4A2 and NR4A3 alterations in salivary gland tumors.
· Virchows Arch · 2023 · PMID 36469101 · validated civic_curation pubmed
Nuclear NR4A3 Immunostaining Is a Specific and Sensitive Novel Marker for Acinic Cell Carcinoma of the Salivary Glands.
· Am J Surg Pathol · 2019 · PMID 31094928 · validated civic_curation pubmed
Analysis of clinicopathologic features and expression of NR4A3 in sinonasal acinic cell carcinoma.
· Mod Pathol · 2022 · PMID 34873305

NR4A3 Fusion + NR4A3 Fusion1
Trabectedin	Extraskeletal Myxoid Chondrosarcoma	Predictive	C	Supports Sensitivity Response	2	accepted	EID12545 In a sub-analysis of a randomized phase II trial in extraskeletal myxoid chondrosarcoma (EWSR1-NR4A3 and TAF15-NR4A3 fusions; n = 2) and mesenchymal chondrosarcoma (HEY1-NCOA2 fusion, n = 6)(trabected… (full text at CIViC) PMID 27418251 · Morioka et al., 2016 · Open in CIViC	civic

NR4A3 Fusion + NR4A3 Fusion1

Trabectedin

Extraskeletal Myxoid Chondrosarcoma

Predictive

Supports Sensitivity Response

accepted

EID12545

In a sub-analysis of a randomized phase II trial in extraskeletal myxoid chondrosarcoma (EWSR1-NR4A3 and TAF15-NR4A3 fusions; n = 2) and mesenchymal chondrosarcoma (HEY1-NCOA2 fusion, n = 6)(trabected… (full text at CIViC)

PMID 27418251 · Morioka et al., 2016 · Open in CIViC

civic

NR4A3 rearrangement1
(diagnostic)	Acinar Cell CarcinomaALIAS	Diagnostic	B	Supports Positive	4	accepted	EID12030 In this study, using genome sequencing the authors identified a t(4;9)(q13;q31) in six acinic cell carcinoma cases (AciCCs). The 4q13 breakpoints were at the secretory Ca-binding phosphoprotein (SCPP… (full text at CIViC) PMID 30664630 · Haller et al., 2019 · Open in CIViC	civic

NR4A3 rearrangement1

(diagnostic)

Acinar Cell CarcinomaALIAS

Diagnostic

Supports Positive

accepted

EID12030

In this study, using genome sequencing the authors identified a t(4;9)(q13;q31) in six acinic cell carcinoma cases (AciCCs). The 4q13 breakpoints were at the secretory Ca-binding phosphoprotein (SCPP… (full text at CIViC)

PMID 30664630 · Haller et al., 2019 · Open in CIViC

civic

NR4A3 Fusion4
(diagnostic)	Acinar Cell CarcinomaALIAS	Diagnostic	B	Supports Positive	4	accepted	EID12816 In this 2023 study, the authors evaluated the diagnostic utility of NR4A3 immunohistochemistry in acinic cell carcinoma (AciCC) of the salivary gland. The cohort included 128 AciCCs, comprising 85 cla… (full text at CIViC) PMID 36469101 · Klubíčková et al., 2023 · Open in CIViC	civic
〃	Acinar Cell CarcinomaALIAS	Diagnostic	B	Supports Positive	4	accepted	EID12828 In this 2019 study, the authors aimed to evaluate the usefulness of NR4A3 immunostaining and compare it with NR4A3 Fluorescence in situ hybridization (FISH) for the differential diagnosis of acinic ce… (full text at CIViC) PMID 31094928 · Haller et al., 2019 · Open in CIViC	civic
〃	Acinar Cell CarcinomaALIAS	Diagnostic	B	Supports Positive	3	accepted	EID12336 In this 2022 study the authors included 4 cases of sinonasal acinic cell carcinoma and 10 acinic cell carcinoma cases of the parotid gland. All four sinonasal patients were male, aged from 27 to 70 ye… (full text at CIViC) PMID 34873305 · Wang et al., 2022 · Open in CIViC	civic
〃	Acinar Cell CarcinomaALIAS	Diagnostic	C	Supports Positive	3	accepted	EID12337 In this 2023 study the authors included 4 cases of acinic cell carcinoma of the salivary gland. The age of the patients ranged from 13 to 16 years, and included 2 males and 2 females. Immunohistochemi… (full text at CIViC) PMID 36169793 · Cole et al., 2023 · Open in CIViC	civic

NR4A3 Fusion4

(diagnostic)

Acinar Cell CarcinomaALIAS

Diagnostic

Supports Positive

accepted

EID12816

In this 2023 study, the authors evaluated the diagnostic utility of NR4A3 immunohistochemistry in acinic cell carcinoma (AciCC) of the salivary gland. The cohort included 128 AciCCs, comprising 85 cla… (full text at CIViC)

PMID 36469101 · Klubíčková et al., 2023 · Open in CIViC

civic

〃

Acinar Cell CarcinomaALIAS

Diagnostic

Supports Positive

accepted

EID12828

In this 2019 study, the authors aimed to evaluate the usefulness of NR4A3 immunostaining and compare it with NR4A3 Fluorescence in situ hybridization (FISH) for the differential diagnosis of acinic ce… (full text at CIViC)

PMID 31094928 · Haller et al., 2019 · Open in CIViC

civic

〃

Acinar Cell CarcinomaALIAS

Diagnostic

Supports Positive

accepted

EID12336

In this 2022 study the authors included 4 cases of sinonasal acinic cell carcinoma and 10 acinic cell carcinoma cases of the parotid gland. All four sinonasal patients were male, aged from 27 to 70 ye… (full text at CIViC)

PMID 34873305 · Wang et al., 2022 · Open in CIViC

civic

〃

Acinar Cell CarcinomaALIAS

Diagnostic

Supports Positive

accepted

EID12337

In this 2023 study the authors included 4 cases of acinic cell carcinoma of the salivary gland. The age of the patients ranged from 13 to 16 years, and included 2 males and 2 females. Immunohistochemi… (full text at CIViC)

PMID 36169793 · Cole et al., 2023 · Open in CIViC

civic