Primitive Neuroectodermal Tumor

cancer family

Identifier: CI-CAN-00000330
Entity page: /cancer/primitive-neuroectodermal-tumor ↗
Edges: 798

Neighbours: 2 genes22 drugs10 trials
Drawn: 34 of 34 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Primitive Neuroectodermal Tumor approved for …APPROVED_FOR8 of 4
← approved for	Everolimussmall_molecule 2 source records aggregated	supports	FDA ORIG	Primitive Neuroectodermal Tumor	2	Regulatory	openfda	graph →
← approved for	Cabozantinibsmall_molecule	supports

Primitive Neuroectodermal Tumor investigated for …INVESTIGATED_FOR10 of 10
← investigated for	Vincristinesmall_molecule	unknown	3	Primitive Neuroectodermal Tumor	1	Curated	chembl	graph →
← investigated for	Thiotepasmall_molecule	unknown	3	Primitive Neuroectodermal Tumor	1	Curated	chembl	graph →
← investigated for	Methotrexatesmall_molecule	unknown	3	Primitive Neuroectodermal Tumor	1	Curated	chembl	graph →
← investigated for	Leucovorinsmall_molecule	unknown	3	Primitive Neuroectodermal Tumor	1	Curated	chembl	graph →
← investigated for	Filgrastimother	unknown	3	Primitive Neuroectodermal Tumor	1	Curated	chembl	graph →
← investigated for	Etoposidesmall_molecule	unknown	3	Primitive Neuroectodermal Tumor	1	Curated	chembl	graph →
← investigated for	Cyclophosphamidesmall_molecule	unknown	3	Primitive Neuroectodermal Tumor	1	Curated	chembl	graph →
← investigated for	Cisplatinsmall_molecule	unknown	3	Primitive Neuroectodermal Tumor	1	Curated	chembl	graph →
← investigated for	Carboplatinsmall_molecule	unknown	3	Primitive Neuroectodermal Tumor	1	Curated	chembl	graph →
← investigated for	Tipifarnibsmall_molecule	unknown	2	Primitive Neuroectodermal Tumor	1	Curated	chembl	graph →

Primitive Neuroectodermal Tumor investigated for …INVESTIGATED_FOR10 of 10

← investigated for

Vincristinesmall_molecule

unknown

Primitive Neuroectodermal Tumor

Curated

Primitive Neuroectodermal Tumor altered in cohorts of …ALTERED_INderived2 of 2
← altered in cohorts of	ALK 64 / 471 cases (14 %) · ssm · nbl_target_gdc · largest of 3 cohorts	—	—	Neuroblastoma	3	Observed	cbioportal	graph →
← altered in cohorts of	ATRX 24 / 223 cases (11 %) · ssm · nbl_msk_2023	—	—	Neuroblastoma	1	Observed	cbioportal	graph →

Primitive Neuroectodermal Tumor investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 109show all (up to 200)
→ investigated in trials for	Cyclophosphamidesmall_molecule 93 trials (22 active) · roll-up of the cancer and its descendants	—	—	Primitive Neuroectodermal Tumor	93	Observed	clinicaltrials	graph →
→ investigated in trials for	Etoposidesmall_molecule 64 trials (9 active) · roll-up of the cancer and its descendants	—	—	Primitive Neuroectodermal Tumor	64	Observed	clinicaltrials	graph →
→ investigated in trials for	Carboplatinsmall_molecule 54 trials (8 active) · roll-up of the cancer and its descendants	—	—	Primitive Neuroectodermal Tumor	54	Observed	clinicaltrials	graph →
→ investigated in trials for	Vincristinesmall_molecule 52 trials (9 active) · roll-up of the cancer and its descendants	—	—	Primitive Neuroectodermal Tumor	52	Observed	clinicaltrials	graph →
→ investigated in trials for	Filgrastimother 44 trials (1 active) · roll-up of the cancer and its descendants	—	—	Primitive Neuroectodermal Tumor	44	Observed	clinicaltrials	graph →
→ investigated in trials for	Melphalansmall molecule 44 trials (5 active) · roll-up of the cancer and its descendants	—	—	Primitive Neuroectodermal Tumor	44	Observed	clinicaltrials	graph →
→ investigated in trials for	Doxorubicinsmall molecule 43 trials (7 active) · roll-up of the cancer and its descendants	—	—	Primitive Neuroectodermal Tumor	43	Observed	clinicaltrials	graph →
→ investigated in trials for	Topotecansmall molecule 40 trials (10 active) · roll-up of the cancer and its descendants	—	—	Primitive Neuroectodermal Tumor	40	Observed	clinicaltrials	graph →
→ investigated in trials for	Temozolomidesmall molecule 39 trials (17 active) · roll-up of the cancer and its descendants	—	—	Primitive Neuroectodermal Tumor	39	Observed	clinicaltrials	graph →
→ investigated in trials for	Cisplatinsmall_molecule 32 trials (4 active) · roll-up of the cancer and its descendants	—	—	Primitive Neuroectodermal Tumor	32	Observed	clinicaltrials	graph →
→ investigated in trials for	Irinotecansmall molecule 32 trials (14 active) · roll-up of the cancer and its descendants	—	—	Primitive Neuroectodermal Tumor	32	Observed	clinicaltrials	graph →
→ investigated in trials for	Busulfansmall molecule 22 trials (3 active) · roll-up of the cancer and its descendants	—	—	Primitive Neuroectodermal Tumor	22	Observed	clinicaltrials	graph →
→ investigated in trials for	Thiotepasmall_molecule 21 trials (5 active) · roll-up of the cancer and its descendants	—	—	Primitive Neuroectodermal Tumor	21	Observed	clinicaltrials	graph →
→ investigated in trials for	Fludarabinesmall molecule 20 trials (7 active) · roll-up of the cancer and its descendants	—	—	Primitive Neuroectodermal Tumor	20	Observed	clinicaltrials	graph →
→ investigated in trials for	Dinutuximabmonoclonal antibody 17 trials (10 active) · roll-up of the cancer and its descendants	—	—	Primitive Neuroectodermal Tumor	17	Observed	clinicaltrials	graph →

Primitive Neuroectodermal Tumor studied in …STUDIED_INderived10 of 673show all (up to 200)
→ studied in	NCT01109394recruiting Comprehensive Omics Analysis of Pediatric and Adult Solid Tumors and Establishment of a Repository for Related Biological Studies · condition mapped ONTOLOGY_EXACT · 673 trials mapped (177 active)	—	—	Neuroblastoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT01445288completed Exploratory Study of Effects of Radiation Therapy in Pediatric Patients With Central Nervous System Tumors · condition mapped ALIAS · 673 trials mapped (177 active)	—	—	Primitive Neuroectodermal Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT06441331Phase 1 · recruiting Phase I Trial to Determine the Dose and Evaluate the PK and Safety of Lutetium Lu 177 Edotreotide Therapy in Pediatric Participants With SSTR-positive Tumors · condition mapped ONTOLOGY_EXACT · 673 trials mapped (177 active)	—	—	Peripheral Primitive Neuroectodermal Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT06172296Phase 3 · recruiting Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma · condition mapped ONTOLOGY_EXACT · 673 trials mapped (177 active)	—	—	Ganglioneuroblastoma, Nodular	1	Observed	clinicaltrials	graph →
→ studied in	NCT06995872Phase 1 · recruiting Phase I Trial of rhIL-15 Plus Dinutuximab Plus Irinotecan/Temozolomide for Children and Young Adults With Relapsed/Refractory Neuroblastoma · condition mapped ONTOLOGY_EXACT · 673 trials mapped (177 active)	—	—	Neuroblastoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04837547Phase 1 · active not recruiting PEACH TRIAL- Precision Medicine and Adoptive Cellular Therapy · condition mapped ONTOLOGY_EXACT · 673 trials mapped (177 active)	—	—	Neuroblastoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT01005654recruiting Prospective Comprehensive Molecular Analysis of Endocrine Neoplasms · condition mapped ONTOLOGY_EXACT · 673 trials mapped (177 active)	—	—	Neuroblastoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT01857934Phase 2 · completed Therapy for Children With Advanced Stage Neuroblastoma · condition mapped ONTOLOGY_EXACT · 673 trials mapped (177 active)	—	—	Neuroblastoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT03210714Phase 2 · active not recruiting Erdafitinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With FGFR Mutations (A Pediatric MATCH Treatment Trial) · condition mapped CURATED_BROADER · 673 trials mapped (177 active)	—	—	Neuroblastoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT03251989completed Rare CNS Tumors Outcomes &Risk · condition mapped ALIAS · 673 trials mapped (177 active)	—	—	Primitive Neuroectodermal Tumor	1	Observed	clinicaltrials	graph →

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