Nerve Sheath Neoplasm

cancer family

Identifier: CI-CAN-00000285
Entity page: /cancer/nerve-sheath-neoplasm ↗
Edges: 274

Neighbours: 3 genes15 drugs10 trials
Drawn: 28 of 28 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Nerve Sheath Neoplasm investigated for …INVESTIGATED_FOR2 of 2
← investigated for	Nivolumabmonoclonal_antibody	unknown	1	Nerve Sheath Neoplasm	1	Curated	chembl	graph →
← investigated for	Ipilimumabmonoclonal_antibody	unknown	1

Nerve Sheath Neoplasm altered in cohorts of …ALTERED_INderived3 of 3
← altered in cohorts of	NF2 31 / 40 cases (78 %) · ssm · schw_ctf_synodos_2025	—	—	Schwannoma	1	Observed	cbioportal	graph →
← altered in cohorts of	NF1 29 / 80 cases (36 %) · ssm · nst_nfosi_ntap	—	—	Nerve Sheath Neoplasm	1	Observed	cbioportal	graph →
← altered in cohorts of	ADPRHL1 24 / 80 cases (30 %) · ssm · nst_nfosi_ntap	—	—	Nerve Sheath Neoplasm	1	Observed	cbioportal	graph →

Nerve Sheath Neoplasm altered in cohorts of …ALTERED_INderived3 of 3

← altered in cohorts of

NF2

31 / 40 cases (78 %) · ssm · schw_ctf_synodos_2025

—

Schwannoma

Observed

Nerve Sheath Neoplasm investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 51show all (up to 200)
→ investigated in trials for	Selumetinibsmall molecule 12 trials (8 active) · roll-up of the cancer and its descendants	—	—	Nerve Sheath Neoplasm	12	Observed	clinicaltrials	graph →
→ investigated in trials for	Doxorubicinsmall molecule 7 trials (2 active) · roll-up of the cancer and its descendants	—	—	Nerve Sheath Neoplasm	7	Observed	clinicaltrials	graph →
→ investigated in trials for	Bevacizumabmonoclonal antibody 5 trials (1 active) · roll-up of the cancer and its descendants	—	—	Nerve Sheath Neoplasm	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Ifosfamidesmall molecule 4 trials (2 active) · roll-up of the cancer and its descendants	—	—	Nerve Sheath Neoplasm	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Nivolumabmonoclonal_antibody 4 trials (3 active) · roll-up of the cancer and its descendants	—	—	Nerve Sheath Neoplasm	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Pazopanibsmall molecule 4 trials (1 active) · roll-up of the cancer and its descendants	—	—	Nerve Sheath Neoplasm	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Selinexorsmall molecule 4 trials (2 active) · roll-up of the cancer and its descendants	—	—	Nerve Sheath Neoplasm	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Everolimussmall molecule 3 trials (0 active) · roll-up of the cancer and its descendants	—	—	Nerve Sheath Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Sirolimussmall molecule 3 trials (0 active) · roll-up of the cancer and its descendants	—	—	Nerve Sheath Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Cixutumumabmonoclonal antibody 2 trials (0 active) · roll-up of the cancer and its descendants	—	—	Nerve Sheath Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Fludarabinesmall molecule 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	Nerve Sheath Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Imatinib Mesylatesmall molecule 2 trials (0 active) · roll-up of the cancer and its descendants	—	—	Nerve Sheath Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Ipilimumabmonoclonal_antibody 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	Nerve Sheath Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Lapatinibsmall molecule 2 trials (0 active) · roll-up of the cancer and its descendants	—	—	Nerve Sheath Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Pembrolizumabmonoclonal antibody 2 trials (1 active) · roll-up of the cancer and its descendants	—	—	Nerve Sheath Neoplasm	2	Observed	clinicaltrials	graph →

Nerve Sheath Neoplasm studied in …STUDIED_INderived10 of 218show all (up to 200)
→ studied in	NCT00924196active not recruiting Natural History Study of Patients With Neurofibromatosis Type I · condition mapped ONTOLOGY_EXACT · 218 trials mapped (86 active)	—	—	Malignant Peripheral Nerve Sheath Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT00314119completed Natural History and Biology of Skin Neurofibromas in Neurofibromatosis Type 1 · condition mapped ONTOLOGY_EXACT · 218 trials mapped (86 active)	—	—	Neurofibroma	1	Observed	clinicaltrials	graph →
→ studied in	NCT01362803Phase 1/Phase 2 · active not recruiting AZD6244 Hydrogen Sulfate for Children With Nervous System Tumors · condition mapped ALIAS · 218 trials mapped (86 active)	—	—	Plexiform Neurofibroma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07844460enrolling by invitation 3D MRE-Based Evaluation of Vestibular Schwannoma Mechanical Properties and Histological Features · condition mapped ONTOLOGY_EXACT · 218 trials mapped (86 active)	—	—	Vestibular Schwannoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04222413Phase 1 · recruiting Metarrestin (ML-246) in Subjects With Metastatic Solid Tumors · condition mapped ONTOLOGY_EXACT · 218 trials mapped (86 active)	—	—	Malignant Peripheral Nerve Sheath Tumor	1	Observed	clinicaltrials	graph →
→ studied in	NCT06175637active not recruiting Observational Study to Evaluate the Effect and Safety of Selumetinib in Pediatric Patients With NF1-PNs · condition mapped ALIAS · 218 trials mapped (86 active)	—	—	Plexiform Neurofibroma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07298083recruiting DoD Award NF230020 Identification of Metabolic Markers and Statistical Prediction of MPNST for Rapid Diagnosis and Assessment of Surgical Margins · condition mapped ALIAS · 218 trials mapped (86 active)	—	—	Neurofibroma	1	Observed	clinicaltrials	graph →
→ studied in	NCT01199978Phase 2 · active not recruiting Hearing Outcomes Using Fractionated Proton Radiation Therapy for Vestibular Schwannoma · condition mapped ONTOLOGY_EXACT · 218 trials mapped (86 active)	—	—	Vestibular Schwannoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07801560completed CyberKnife Radiotherapy for the Treatment of Schwannomas · condition mapped ALIAS · 218 trials mapped (86 active)	—	—	Vestibular Schwannoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT05622344NA · recruiting StableEyes With Active Neurofeedback · condition mapped ONTOLOGY_EXACT · 218 trials mapped (86 active)	—	—	Vestibular Schwannoma	1	Observed	clinicaltrials	graph →

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