Gene

STAG2

STAG2 cohesin complex component

Explore in graph →CI-GENE-00033984HGNC:11355 ENSG00000101972 NCBI 10735 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (7)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–7 of 7 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
STAG2 Fusion1
(diagnostic)	Childhood B-cell Acute Lymphoblastic LeukemiaUNRESOLVED	Diagnostic	C	Supports Positive	2	submitted

Cohorts

Alteration frequency by cohort (144)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved144 cohort rows (showing 44, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Kidney Renal Clear Cell Carcinoma (TCGA, Nature 2013) kirc_tcga_pub	Clear Cell Renal Cell Carcinoma	Ssm

Literature

Linked publications (4)

25 per page, newest first.

pubmedPublishedShowing 1–4 of 4 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

The genomic landscape of pediatric Ewing sarcoma.
· Cancer Discov · 2014 · PMID 25186949 · validated civic_curation pubmed
Complete loss of STAG2 expression is an indicator of good prognosis in patients with bladder cancer.
· Tumour Biol · 2016 · PMID 26838030 · validated civic_curation pubmed
Mutations in the cohesin complex in acute myeloid leukemia: clinical and prognostic implications.
· Blood · 2014 · PMID 24335498 · validated civic_curation pubmed
Loss of cohesin complex components STAG2 or STAG3 confers resistance to BRAF inhibition in melanoma.
· Nat Med · 2016 · PMID 27500726 · validated civic_curation pubmed

STAG2 MUTATION3
(prognostic)	Bone Ewing SarcomaALIAS	Prognostic	B	Supports Poor Outcome	4	accepted	EID1697 In a study of 96 Ewing sarcoma tumors, 15% showed heterogenous loss of STAG2 expression in IHC analysis. Of those with STAG2 expression loss, 88% presented with metastatic disease compared to only 27… (full text at CIViC) PMID 25186949 · Crompton et al., 2014 · Open in CIViC	civic
〃	Acute Myeloid LeukemiaCURATED_BROADER	Prognostic	B	Supports Poor Outcome	3	submitted	EID6947 Sequencing of 93 secondary acute myeloid leukemias (AML) compared to 180 TCGA de novo AMLs identified STAG2 mutations had >95% sensitivity for being diagnostic of secondary AML, identifying a patient … (full text at CIViC) PMID 25550361 · Lindsley et al., 2015 · Open in CIViC	civic
〃	Acute Myeloid LeukemiaCURATED_BROADER	Prognostic	B	Does Not Support Poor Outcome	2	accepted	EID7451 In a retrospective cohort study of 389 uniformly treated acute myeloid leukemia (AML) patients, 23 patients harbored mutations in genes of the cohesin complex including 5 who harbored mutations in STA… (full text at CIViC) PMID 24335498 · Thol et al., 2014 · Open in CIViC	civic

STAG2 MUTATION3

(prognostic)

Bone Ewing SarcomaALIAS

Prognostic

Supports Poor Outcome

accepted

EID1697

In a study of 96 Ewing sarcoma tumors, 15% showed heterogenous loss of STAG2 expression in IHC analysis. Of those with STAG2 expression loss, 88% presented with metastatic disease compared to only 27… (full text at CIViC)

PMID 25186949 · Crompton et al., 2014 · Open in CIViC

civic

〃

Acute Myeloid LeukemiaCURATED_BROADER

Prognostic

Supports Poor Outcome

submitted

EID6947

Sequencing of 93 secondary acute myeloid leukemias (AML) compared to 180 TCGA de novo AMLs identified STAG2 mutations had >95% sensitivity for being diagnostic of secondary AML, identifying a patient … (full text at CIViC)

PMID 25550361 · Lindsley et al., 2015 · Open in CIViC

civic

〃

Acute Myeloid LeukemiaCURATED_BROADER

Prognostic

Does Not Support Poor Outcome

accepted

EID7451

In a retrospective cohort study of 389 uniformly treated acute myeloid leukemia (AML) patients, 23 patients harbored mutations in genes of the cohesin complex including 5 who harbored mutations in STA… (full text at CIViC)

PMID 24335498 · Thol et al., 2014 · Open in CIViC

civic

STAG2 Underexpression3
(prognostic)	Bladder Carcinoma	Prognostic	B	Supports Better Outcome	2	accepted	EID984 Tumor samples from 125 patients with bladder cancer were assessed by IHC for STAG2 expression. STAG2-negativity was associated with lower histological grade (p = 0.009). Complete loss of STAG2 express… (full text at CIViC) PMID 26838030 · Qiao et al., 2016 · Open in CIViC	civic
〃	Bladder Urothelial Papillary CarcinomaUNRESOLVED	Prognostic	B	Supports Better Outcome	2	submitted	EID7207 In a cohort of 34 patients with non-muscle invasive papillary urothelial carcinoma of the bladder following transurethral resection, with patients were stratified into two subgroups according to tumou… (full text at CIViC) PMID 24121789 · Solomon et al., 2013 · Open in CIViC	civic
Vemurafenib	Melanoma	Predictive	D	Supports Resistance	4	accepted	EID1659 A375 melanoma cells containing an inducible shRNA for STAG2 were grown as xenograft tumors in nude mice. The mice in which STAG2 was silenced had tumors that were less sensitive to vemurafenib-induced… (full text at CIViC) PMID 27500726 · Shen et al., 2016 · Open in CIViC	civic

STAG2 Underexpression3

(prognostic)

Bladder Carcinoma

Prognostic

Supports Better Outcome

accepted

EID984

Tumor samples from 125 patients with bladder cancer were assessed by IHC for STAG2 expression. STAG2-negativity was associated with lower histological grade (p = 0.009). Complete loss of STAG2 express… (full text at CIViC)

PMID 26838030 · Qiao et al., 2016 · Open in CIViC

civic

〃

Bladder Urothelial Papillary CarcinomaUNRESOLVED

Prognostic

Supports Better Outcome

submitted

EID7207

In a cohort of 34 patients with non-muscle invasive papillary urothelial carcinoma of the bladder following transurethral resection, with patients were stratified into two subgroups according to tumou… (full text at CIViC)

PMID 24121789 · Solomon et al., 2013 · Open in CIViC

civic

Vemurafenib

Melanoma

Predictive

Supports Resistance

accepted

EID1659

A375 melanoma cells containing an inducible shRNA for STAG2 were grown as xenograft tumors in nude mice. The mice in which STAG2 was silenced had tumors that were less sensitive to vemurafenib-induced… (full text at CIViC)

PMID 27500726 · Shen et al., 2016 · Open in CIViC

civic