STAG2 Underexpression

CI-VAR-00004407Explore in graph →CIViC 422

Curated evidence

Evidence by cancer (3 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–3 of 3 evidence items across 3 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Bladder Carcinoma1
STAG2 Underexpression	(prognostic)	Prognostic	B	Supports Better Outcome	2	accepted	EID984 Tumor samples from 125 patients with bladder cancer were assessed by IHC for STAG2 expression. STAG2-negativity was associated with lower histological grade (p = 0.009). Complete loss of STAG2 express… (full text at CIViC) PMID 26838030 · Qiao et al., 2016 · Open in CIViC	civic
Melanoma1
STAG2 Underexpression	Vemurafenib	Predictive	D	Supports Resistance	4	accepted	EID1659 A375 melanoma cells containing an inducible shRNA for STAG2 were grown as xenograft tumors in nude mice. The mice in which STAG2 was silenced had tumors that were less sensitive to vemurafenib-induced… (full text at CIViC) PMID 27500726 ·

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Bladder Urothelial Papillary Carcinoma1unmapped disease
STAG2 Underexpression	(prognostic)	Prognostic	B	Supports Better Outcome	2	submitted	EID7207 In a cohort of 34 patients with non-muscle invasive papillary urothelial carcinoma of the bladder following transurethral resection, with patients were stratified into two subgroups according to tumou… (full text at CIViC) PMID 24121789 · Solomon et al., 2013 · Open in CIViC	civic