Publication
Loss of cohesin complex components STAG2 or STAG3 confers resistance to BRAF inhibition in melanoma.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
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Linked entities
Linked entities (6)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 6
- cancerMelanomacivic_curation1.00
- drugVemurafenibcivic_curation1.00
- geneSTAG2civic_curation1.00
- geneSTAG3civic_curation1.00
- variantSTAG2 Underexpressioncivic_curation1.00
- variantSTAG3 Underexpressioncivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 27500726
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| STAG2 Underexpression1 | ||||||||
| Vemurafenib | Melanoma | Predictive | D | Supports Resistance | 4 | accepted | EID1659A375 melanoma cells containing an inducible shRNA for STAG2 were grown as xenograft tumors in nude mice. The mice in which STAG2 was silenced had tumors that were less sensitive to vemurafenib-induced… (full text at CIViC) PMID 27500726 · Shen et al., 2016 · Open in CIViC | civic |
| STAG3 Underexpression1 | ||||||||
| Vemurafenib | Melanoma | Predictive | D | Supports Resistance | 4 | accepted | EID1660A375 melanoma cells containing an inducible shRNA for STAG3 were grown as xenograft tumors in nude mice. The mice in which STAG3 was silenced had tumors that were less sensitive to vemurafenib-induced… (full text at CIViC) PMID 27500726 · Shen et al., 2016 · Open in CIViC | civic |