Gene

SDHB

succinate dehydrogenase complex iron sulfur subunit B

Explore in graph →CI-GENE-00030089HGNC:10681 ENSG00000117118 NCBI 6390 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (3)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–3 of 3 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
SDHB c.314T>A1
(predisposing)	Paraganglioma	Predisposing	C	Supports Predisposition	2	submitted	EID13231 A germline SDHB c.314T>A variant was found in a 37 year old man with metastatic sympathetic abdominal paraganglioma. The variant was originally classified as a VUS. The loss of SDHB expression on the … (full text at CIViC) PMID 40213107 · Bernardi et al., 2025 · Open in CIViC	civic
SDHB Mutation1
Metformin + VandetanibCombination	Hereditary Renal Cell Carcinoma	Predictive	B	Supports Sensitivity Response	2	submitted	EID7959 Vandetanib in Combination With Metformin is tested in Phase II trial in People With HLRCC or SDH-Associated Kidney Cancer or Sporadic Papillary Renal Cell Carcinoma

Cohorts

Alteration frequency by cohort (13)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved13 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Hereditary SDHB-Mutant Pheochromocytomas and Paragangliomas (A5 Consortium, Nature Comm 2025) hnsc_a5consortium_2025	Head and Neck Squamous Cell Carcinoma	Ssm

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Paraganglioma in a 13-year-old girl: a novel SDHB gene mutation in the family?
· Cancer Genet Cytogenet · 2010 · PMID 20193854 · validated civic_curation pubmed

SDHB p.193_196dupSTSC (c.577_588dupAGCACCAGCTGC)1
(predisposing)	Paraganglioma	Predisposing	C	Supports Uncertain Significance	2	accepted	EID6442 An in-frame duplication of 12 nucleotides resulting in the insertion of 4 amino acids within exon 6 of the SDHB gene was found in a single female case (a 13-year-old) with confirmed paraganglioma. The… (full text at CIViC) PMID 20193854 · Musil et al., 2010 · Open in CIViC	civic

SDHB p.193_196dupSTSC (c.577_588dupAGCACCAGCTGC)1

(predisposing)

Paraganglioma

Predisposing

Supports Uncertain Significance

accepted

EID6442

An in-frame duplication of 12 nucleotides resulting in the insertion of 4 amino acids within exon 6 of the SDHB gene was found in a single female case (a 13-year-old) with confirmed paraganglioma. The… (full text at CIViC)

PMID 20193854 · Musil et al., 2010 · Open in CIViC

civic