SDHB p.193_196dupSTSC (c.577_588dupAGCACCAGCTGC)

CI-VAR-00005025Explore in graph →NP_002991.2:p.193_196dupSTSCNM_003000.2:c.577_588dupAGCACCAGCTGCCIViC 2411

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Paraganglioma1
SDHB p.193_196dupSTSC (c.577_588dupAGCACCAGCTGC)	(predisposing)	Predisposing	C	Supports Uncertain Significance	2	accepted	EID6442 An in-frame duplication of 12 nucleotides resulting in the insertion of 4 amino acids within exon 6 of the SDHB gene was found in a single female case (a 13-year-old) with confirmed paraganglioma. The… (full text at CIViC) PMID 20193854 · Musil et al., 2010 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.