RHOA MUTATION

CI-VAR-00002625Explore in graph →CIViC 665

Curated evidence

Evidence by cancer (3 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–3 of 3 evidence items across 3 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Burkitt Lymphoma1
RHOA MUTATION	(oncogenic)	Oncogenic	E	Supports Oncogenicity	3	submitted	EID11830 Described in multiple genome-wide studies of BL PMID 30617194 · Grande et al., 2019 · Open in CIViC	civic
Diffuse Large B-Cell Lymphoma1
RHOA MUTATION	(oncogenic)	Oncogenic	E	Supports Oncogenicity	4	submitted	EID11981 One of the first genes found to be affected by aberrant somatic hypermutation in DLBCL PMID 11460166 · Pasqualucci et al., 2001 · Open in CIViC	civic
Gastric Carcinoma

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.