Gene

PTPRT

protein tyrosine phosphatase receptor type T

Explore in graph →CI-GENE-00022555HGNC:9682 ENSG00000196090 NCBI 11122 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
PTPRT Promoter Hypermethylation1
JSI-124 + StatticSubstitutes	Head and Neck Squamous Cell Carcinoma	Predictive	D	Supports Sensitivity Response	2	accepted	EID817 PTPRT promoter hypermethylation was associated with increased sensitivity to STAT3 inhibition in this preclinical study in HNSCC. The authors found that PTPRT promoter methylation and sensitivity to S… (full text at CIViC) PMID 25982282 · Peyser et al., 2016 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (196)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved196 cohort rows (showing 50, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Rectal Cancer (MSK,Nature Medicine 2019) rectal_msk_2019	Colorectal Adenocarcinoma	Ssm	18

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Frequent promoter hypermethylation of PTPRT increases STAT3 activation and sensitivity to STAT3 inhibition in head and neck cancer.
· Oncogene · 2016 · PMID 25982282 · validated civic_curation pubmed