Publication
Frequent promoter hypermethylation of PTPRT increases STAT3 activation and sensitivity to STAT3 inhibition in head and neck cancer.
Authors not recorded
Oncogene2016PMID 25982282PMC4651851stubpubmedProvenance
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
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Linked entities
Linked entities (5)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 5
- cancerHead and Neck Squamous Cell Carcinomacivic_curation1.00
- drugJSI-124civic_curation1.00
- drugStatticcivic_curation1.00
- genePTPRTcivic_curation1.00
- variantPTPRT Promoter Hypermethylationcivic_curation1.00
Curated evidence
Evidence citing this paper (1)
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 25982282
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| PTPRT Promoter Hypermethylation1 | ||||||||
| JSI-124 + StatticSubstitutes | Head and Neck Squamous Cell Carcinoma | Predictive | D | Supports Sensitivity Response | 2 | accepted | EID817PTPRT promoter hypermethylation was associated with increased sensitivity to STAT3 inhibition in this preclinical study in HNSCC. The authors found that PTPRT promoter methylation and sensitivity to S… (full text at CIViC) PMID 25982282 · Peyser et al., 2016 · Open in CIViC | civic |