Publication
The Highly Recurrent PP2A Aα-Subunit Mutation P179R Alters Protein Structure and Impairs PP2A Enzyme Function to Promote Endometrial Tumorigenesis.
Authors not recorded
Cancer Res2019PMID 31142515PMC6724736stubpubmedProvenance
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
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Linked entities
Linked entities (2)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 2
- genePPP2R1Acivic_curation1.00
- variantPPP2R1A P179Rcivic_curation1.00
Curated evidence
Evidence citing this paper (1)
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 31142515
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| PPP2R1A P179R1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 4 | accepted | EID9212Immunoprecipitation experiments in a serous endometrial carcinoma cell line that expressed V5 tagged PPP2R1A P179R protein revealed that binding of PPP2R1A to the PP2A holoenzyme complex members was s… (full text at CIViC) PMID 31142515 · Taylor et al., 2019 · Open in CIViC | civic |