PIK3R2 G373R

CI-VAR-00001727Explore in graph →CIViC 3381

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Unmapped disease1unmapped disease
PIK3R2 G373R	(functional)	Functional	D	Supports Gain Of Function	1	accepted	EID9420 Lymphoblastoid cell lines were derived from patients with megalencephaly syndromes, who had the PIK3R2 p.G373R mutation. PIP3 immunostaining was used to compared PI3K activity among mutant and control… (full text at CIViC) PMID 22729224 · Rivière et al., 2012 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.