PAX5 — gene · CancerIndex

Curated evidence

Clinical evidence (8)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–8 of 8 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
CDKN2A Deletion + CDKN2B Deletion + ERG Deletion + IKZF1 Deletion + CRLF2 Fusion + PAX5 DeletionPAX5 CDKN2B ERG IKZF1 CRLF2 CDKN2A1
(prognostic)	B Lymphoblastic Leukemia/LymphomaCURATED_BROADER	Prognostic	B	Supports Poor Outcome	5	submitted	EID7786 83 of 991 cases of pediatric B-cell precursor (BCP) acute lymphoblastic leukemia (ALL) were found to have IKZF1 deletion, previously reported as an independent factor associated with a poor prognosis.… (full text at CIViC) PMID 29498923 · Stanulla et al., 2018 · Open in CIViC	civic
PAX5 P80R4
(diagnostic)

Cohorts

Alteration frequency by cohort (68)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved68 cohort rows (showing 18, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Gallbladder Cancer (MSK, Cancer 2018) gbc_msk_2018	Gallbladder Carcinoma	Ssm	1

Literature

Linked publications (5)

25 per page, newest first.

pubmedPublishedShowing 1–5 of 5 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

PAX5-driven subtypes of B-progenitor acute lymphoblastic leukemia.
· Nat Genet · 2019 · PMID 30643249 · validated civic_curation pubmed
Genomic landscape of pediatric B-other acute lymphoblastic leukemia in a consecutive European cohort.
· Haematologica · 2019 · PMID 30630978 · validated civic_curation pubmed
PAX5 P80R mutation identifies a novel subtype of B-cell precursor acute lymphoblastic leukemia with favorable outcome.
· Blood · 2019 · PMID 30510083 · validated civic_curation pubmed
Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases.
· Proc Natl Acad Sci U S A · 2018 · PMID 30487223 · validated civic_curation

PAX5 Fusion3
(diagnostic)	B-lymphoblastic Leukemia With PAX5altUNRESOLVED	Diagnostic	B	Supports Positive	5	accepted	EID12867 This landmark study provided revised classification of B-lymphoblastic leukemia (B-ALL) based on integrated genomic findings from 1,988 childhood and adult B-ALLs. All cases were subjected to RNA-seq … (full text at CIViC) PMID 30643249 · Gu et al., 2019 · Open in CIViC	civic
〃	B-lymphoblastic Leukemia With PAX5altUNRESOLVED	Diagnostic	B	Supports Positive	5	accepted	EID12868 This European population-based cohort study examined the genomic landscape of 110 consecutively diagnosed childhood (aged 1-18 years) “B-other” lymphoblastic leukemia (ALL) cases, collected over 7 yea… (full text at CIViC) PMID 30630978 · Zaliova et al., 2019 · Open in CIViC	civic
〃	B-lymphoblastic Leukemia With PAX5altUNRESOLVED	Diagnostic	B	Supports Positive	3	accepted	EID12869 This large FISH-based screening study systematically identified PAX5 fusion partners in a cohort of 446 patients with childhood acute lymphoblastic leukemia (ALL). Interphase FISH was performed on all… (full text at CIViC) PMID 19020546 · Nebral et al., 2009 · Open in CIViC	civic