NUP214 — gene · CancerIndex

Curated evidence

Clinical evidence (5)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–5 of 5 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
NUP214 Fusion5
(diagnostic)	Acute Myeloid Leukemia With T(6;9) (p23;q34.1)UNRESOLVED	Diagnostic	B	Supports Positive	4	accepted	EID12123 This retrospective study from five independent study sites gathered diagnostic and prognostic data regarding the t(6;9)(p23;q34), known to result in a DEK::NUP214 fusion. Data from 20 different treatm… (full text at CIViC) PMID 16628187 · Slovak et al., 2006 · Open in CIViC	civic
(prognostic)	Acute Myeloid Leukemia With T(6;9) (p23;q34.1)UNRESOLVED	Prognostic	B	Supports Poor Outcome	4	submitted	EID12124 This retrospective study gathered diagnostic and prognostic data for acute myeloid leukemia (AML) with the t(6;9)(p23;q34), known to result in a DEK::NUP214 fusion from 20 different treatment protocol… (full text at CIViC) PMID ·

Cohorts

Alteration frequency by cohort (8)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved8 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Pediatric Pan-cancer (Columbia U, Genome Med 2016) mixed_pipseq_2017	unmapped	Ssm	13	103	12.6%

Literature

Linked publications (3)

25 per page, newest first.

pubmedPublishedShowing 1–3 of 3 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

A retrospective study of 69 patients with t(6;9)(p23;q34) AML emphasizes the need for a prospective, multicenter initiative for rare 'poor prognosis' myeloid malignancies.
· Leukemia · 2006 · PMID 16628187 · validated civic_curation pubmed
Acute myeloid leukaemia (AML) with t(6;9)(p23;q34) is associated with poor outcome in childhood AML regardless of FLT3-ITD status: a report from the Children's Oncology Group.
· Br J Haematol · 2014 · PMID 24661089 · validated civic_curation pubmed
t(6;9)(p22;q34)/DEK-NUP214-rearranged pediatric myeloid leukemia: an international study of 62 patients.
· Haematologica · 2014 · PMID 24441146 · validated civic_curation pubmed