Gene

NEDD9

neural precursor cell expressed, developmentally down-regulated 9

Explore in graph →CI-GENE-00016565HGNC:7733 ENSG00000111859 NCBI 4739 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
NEDD9 EXPRESSION1
(prognostic)	Hepatocellular Carcinoma	Prognostic	B	Supports Poor Outcome	3	accepted	EID1059 IHC was performed in 123 hepatocellular carcinoma tissues and their adjacent normal liver tissues for protein expression of HEF1 (NEDD9). Overexpression of HEF1 protein was observed in HCC tissue when… (full text at CIViC) PMID 26893853 · Li et al., 2016 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (2)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved2 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Breast Cancer Xenografts (British Columbia, Nature 2015) brca_bccrc_xenograft_2014	Invasive Breast Carcinoma	Ssm	14

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

High expression of HEF1 predicts a poorer prognosis of hepatocellular carcinoma: A retrospective study.
· Mol Clin Oncol · 2016 · PMID 26893853 · validated civic_curation pubmed