Gene

NCOA3

nuclear receptor coactivator 3

Explore in graph →CI-GENE-00016366HGNC:7670 ENSG00000124151 NCBI 8202 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (5)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–5 of 5 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
NCOA2 Fusion + NCOA3 Fusion + NCOA2 FusionNCOA3 NCOA21
(diagnostic)	Malignant Uterine NeoplasmALIAS	Diagnostic	C	Supports Positive	2	submitted	EID12701 In uterine tumors resembling ovarian sex cord tumor (UTROSCT; n = 4), RNA sequencing identified recurrent ESR1::NCOA3 (n = 2), ESR1::NCOA2 (n = 1), and GREB1::NCOA2 (n = 1) fusions, involving NCOA2/3 … (full text at CIViC) PMID 30273195 · Dickson et al., 2019 · Open in CIViC	civic
CITED2 Fusion + NCOA3 Fusion + ESR1 Fusion + NCOA2 Fusion + GREB1 FusionNCOA3 NCOA2 CITED2 ESR1 GREB11

Cohorts

Alteration frequency by cohort (94)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved94 cohort rows (showing 44, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Esophagogastric Cancer (MSK, J Natl Cancer Inst 2023) egc_msk_2023	unmapped	Ssm	14	810

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Prognostic relevance of AIB1 (NCoA3) amplification and overexpression in breast cancer.
· Breast Cancer Res Treat · 2013 · PMID 23322234 · validated civic_curation pubmed