NCOA2 — gene · CancerIndex

Curated evidence

Clinical evidence (16)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–16 of 16 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
NCOA2 Fusion + NCOA3 Fusion + NCOA2 FusionNCOA3 NCOA21
(diagnostic)	Malignant Uterine NeoplasmALIAS	Diagnostic	C

Cohorts

Alteration frequency by cohort (10)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved10 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Urothelial Carcinoma (BCAN/HCRN, Nat Commun 2022) blca_bcan_hcrn_2022	Bladder Urothelial Carcinoma	Ssm	17

Literature

Linked publications (10)

25 per page, newest first.

pubmedPublishedShowing 1–10 of 10 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Identification of a novel, recurrent HEY1-NCOA2 fusion in mesenchymal chondrosarcoma based on a genome-wide screen of exon-level expression data.
· Genes Chromosomes Cancer · 2012 · PMID 22034177 · validated civic_curation pubmed
Detection of HEY1-NCOA2 fusion by fluorescence in-situ hybridization in formalin-fixed paraffin-embedded tissues as a possible diagnostic tool for mesenchymal chondrosarcoma.
· Pathol Int · 2012 · PMID 23252872 · validated civic_curation pubmed
Are meningeal hemangiopericytoma and mesenchymal chondrosarcoma the same?: a study of HEY1-NCOA2 fusion.
· Am J Clin Pathol · 2013 · PMID 24124145 · validated civic_curation pubmed
A Molecular Study of Pediatric Spindle and Sclerosing Rhabdomyosarcoma: Identification of Novel and Recurrent VGLL2-related Fusions in Infantile Cases.

NCOA2 Fusion8
(diagnostic)	Mesenchymal Chondrosarcoma	Diagnostic	B	Supports Positive	4	accepted	EID7008 A HEY1-NCOA2 fusion joining exon 4 of HEY1 to exon 13 of NCOA2 was identified in 10 mesenchymal chondrosarcomas but was absent from all other sarcoma types tested including other chondrosarcoma subtyp… (full text at CIViC) PMID 22034177 · Wang et al., 2012 · Open in CIViC	civic
〃	Mesenchymal Chondrosarcoma	Diagnostic	B	Supports Positive	4	submitted	EID7025 Meningeal hemangiopericytoma (HPC) and mesenchymal chondrosarcoma (MC) are aggressive neoplasms with overlapping clinical presentations and morphology. Thirteen FFPE samples of MC (9 females, 4 males)… (full text at CIViC) PMID 24124145 · Fritchie et al., 2013 · Open in CIViC	civic
〃	Mesenchymal Chondrosarcoma	Diagnostic	B	Supports Positive	4	submitted	EID7026 FISH was used to detect HEY1-NCOA2 fusions in 10 paraffin embedded samples from patients diagnosed with mesenchymal chondrosarcoma. HEY1 and NCOA2 are located on same chromosome but generate distinct … (full text at CIViC) PMID 23252872 · Nakayama et al., 2012 · Open in CIViC	civic
〃	Mesenchymal Chondrosarcoma	Diagnostic	B	Supports Positive	4	accepted	EID7124 FISH was used to detect HEY1-NCOA2 fusions in 10 paraffin embedded samples from patients diagnosed with mesenchymal chondrosarcoma. HEY1 and NCOA2 are located on the same chromosome but generate disti… (full text at CIViC) PMID 23252872 · Nakayama et al., 2012 · Open in CIViC	civic
〃	Mesenchymal Chondrosarcoma	Diagnostic	B	Supports Positive	4	accepted	EID7125 Meningeal hemangiopericytoma (HPC) and mesenchymal chondrosarcoma (MC) are aggressive neoplasms with overlapping clinical presentations and morphology. Thirteen FFPE samples of MC (9 females, 4 males)… (full text at CIViC) PMID 24124145 · Fritchie et al., 2013 · Open in CIViC	civic
〃	Mesenchymal Chondrosarcoma	Diagnostic	B	Supports Positive	2	accepted	EID7017 6 of 6 patients with mesenchymal chondrosarcoma and sufficient tissue tested positive for NCOA2 rearrangments by FISH supporting that NCOA2 rearrangements (presumably HEY1-NCOA2 translocations) are pr… (full text at CIViC) PMID 26146478 · Bishop et al., 2015 · Open in CIViC	civic
Imatinib	Mesenchymal Chondrosarcoma	Predictive	D	Supports Sensitivity Response	2	submitted	EID10798 In two independent in-vitro and PDX models of HEY1::NCOA2 fusion positive mesenchymal chondrosarcoma, imatinib demonstrated a highly selective cytotoxic effect and reduction of growth. PMID 34837064 · Safaric Tepes et al., 2022 · Open in CIViC	civic
Trabectedin	Mesenchymal Chondrosarcoma	Predictive	C	Supports Sensitivity Response	2	accepted	EID12585 In a sub-analysis of a randomized phase II trial in extraskeletal myxoid chondrosarcoma (EWSR1-NR4A3 and TAF15-NR4A3 fusions) and mesenchymal chondrosarcoma (HEY1-NCOA2 fusion)(trabectedin n = 5; BSC … (full text at CIViC) PMID 27418251 · Morioka et al., 2016 · Open in CIViC	civic

NCOA2 Fusion5
(diagnostic)	Spindle Cell Rhabdomyosarcoma	Diagnostic	B	Supports Positive	4	accepted	EID12699 In this 2025 retrospective study, 14 spindle cell rhabdomyosarcoma (SCRMS) cases previously identified as possessing ZFP64::NCOA2 or ZFP64::NCOA3 fusions were pulled from clinical archives to assess c… (full text at CIViC) PMID 41075874 · Dehner et al., 2025 · Open in CIViC	civic
〃	Spindle Cell Rhabdomyosarcoma	Diagnostic	B	Supports Positive	3	accepted	EID11566 In this 2016 study, the authors analyzed 26 pediatric spindle and sclerosing rhabdomyosarcomas (SRMS) using FISH, targeted DNA, and whole transcriptome sequencing to define their molecular landscape. … (full text at CIViC) PMID 26501226 · Alaggio et al., 2016 · Open in CIViC	civic
(prognostic)	Spindle Cell Rhabdomyosarcoma	Prognostic	B	Supports Better Outcome	3	accepted	EID11567 This study looked at 26 spindle cell and sclerosing rhabdomyosarcomas. 11 were congenital/infantile type diagnosed at birth or within one year of age, 10 of which harbored recurrent fusions involving … (full text at CIViC) PMID 26501226 · Alaggio et al., 2016 · Open in CIViC	civic
(diagnostic)	Spindle Cell Rhabdomyosarcoma	Diagnostic	B	Supports Positive	3	accepted	EID12727 In this 2022 study, the authors included 40 patients aged ≤12 months diagnosed with spindle cell rhabdomyosarcoma (SCRMS) enrolled in international trials and registries, of whom 39 presented with loc… (full text at CIViC) PMID 35452896 · Whittle et al., 2022 · Open in CIViC	civic
〃	Spindle Cell Rhabdomyosarcoma	Diagnostic	C	Supports Positive	3	accepted	EID12731 In this 2013 study, the authors included 21 spindle cell and sclerosing rhabdomyosarcomas (RMS), and a control group of 4 embryonal RMS and 3 ectomesenchymomas. RNA sequencing and FISH were utilized t… (full text at CIViC) PMID 23463663 · Mosquera et al., 2013 · Open in CIViC	civic