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Variants & evidence
8 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.
| Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|
| NCOA2 Fusion8 | |||||||
| (diagnostic) | Diagnostic | B | Supports Positive | 4 | accepted | EID7008A HEY1-NCOA2 fusion joining exon 4 of HEY1 to exon 13 of NCOA2 was identified in 10 mesenchymal chondrosarcomas but was absent from all other sarcoma types tested including other chondrosarcoma subtyp… (full text at CIViC) PMID 22034177 · Wang et al., 2012 · Open in CIViC | civic |
| 〃 | Diagnostic | B | Supports Positive | 4 | submitted | EID7025Meningeal hemangiopericytoma (HPC) and mesenchymal chondrosarcoma (MC) are aggressive neoplasms with overlapping clinical presentations and morphology. Thirteen FFPE samples of MC (9 females, 4 males)… (full text at CIViC) PMID 24124145 · Fritchie et al., 2013 · Open in CIViC | civic |
| 〃 | Diagnostic | B | Supports Positive | 4 | submitted | EID7026FISH was used to detect HEY1-NCOA2 fusions in 10 paraffin embedded samples from patients diagnosed with mesenchymal chondrosarcoma. HEY1 and NCOA2 are located on same chromosome but generate distinct … (full text at CIViC) PMID 23252872 · Nakayama et al., 2012 · Open in CIViC | civic |
| 〃 | Diagnostic | B | Supports Positive | 4 | accepted | EID7124FISH was used to detect HEY1-NCOA2 fusions in 10 paraffin embedded samples from patients diagnosed with mesenchymal chondrosarcoma. HEY1 and NCOA2 are located on the same chromosome but generate disti… (full text at CIViC) PMID 23252872 · Nakayama et al., 2012 · Open in CIViC | civic |
| 〃 | Diagnostic | B | Supports Positive | 4 | accepted | EID7125Meningeal hemangiopericytoma (HPC) and mesenchymal chondrosarcoma (MC) are aggressive neoplasms with overlapping clinical presentations and morphology. Thirteen FFPE samples of MC (9 females, 4 males)… (full text at CIViC) PMID 24124145 · Fritchie et al., 2013 · Open in CIViC | civic |
| 〃 | Diagnostic | B | Supports Positive | 2 | accepted | EID70176 of 6 patients with mesenchymal chondrosarcoma and sufficient tissue tested positive for NCOA2 rearrangments by FISH supporting that NCOA2 rearrangements (presumably HEY1-NCOA2 translocations) are pr… (full text at CIViC) PMID 26146478 · Bishop et al., 2015 · Open in CIViC | civic |
| Imatinib | Predictive | D | Supports Sensitivity Response | 2 | submitted | EID10798In two independent in-vitro and PDX models of HEY1::NCOA2 fusion positive mesenchymal chondrosarcoma, imatinib demonstrated a highly selective cytotoxic effect and reduction of growth. PMID 34837064 · Safaric Tepes et al., 2022 · Open in CIViC | civic |
| Trabectedin | Predictive | C | Supports Sensitivity Response | 2 | accepted | EID12585In a sub-analysis of a randomized phase II trial in extraskeletal myxoid chondrosarcoma (EWSR1-NR4A3 and TAF15-NR4A3 fusions) and mesenchymal chondrosarcoma (HEY1-NCOA2 fusion)(trabectedin n = 5; BSC … (full text at CIViC) PMID 27418251 · Morioka et al., 2016 · Open in CIViC | civic |
Data updated 23 hours agoSource updated unknownsource: civic (CC0)
Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.