NBN — gene · CancerIndex

Curated evidence

Clinical evidence (2)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
NBN Loss1
GPI-15427	Malignant Head and Neck NeoplasmALIAS	Predictive	D	Supports Sensitivity Response	3	submitted	EID1954 This study shows a significant antitumor effect of concurrent NBN downregulation (and MRN complex disruption) and PARP inhibition on HNSCC cells. PMID 25324139 · Lajud et al., 2014 · Open in CIViC	civic
ATM Loss + BRCA2 Loss + MUS81 Loss + NBN Loss + RAD51B LossRAD51B BRCA2 MUS81 NBN ATM1
Olaparib	Malignant Ovarian Neoplasm	Predictive	D

Cohorts

Alteration frequency by cohort (73)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved73 cohort rows (showing 23, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
MSK-CHORD (MSK, Nature 2024) msk_chord_2024	unmapped	Ssm	292	25,040	1.2%

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.