Gene

RAD51B

RAD51 paralog B

Explore in graph →CI-GENE-00022865HGNC:9822 ENSG00000182185 NCBI 5890 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (2)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
ATM Loss + BRCA2 Loss + MUS81 Loss + NBN Loss + RAD51B LossRAD51B BRCA2 MUS81 NBN ATM1
Olaparib	Malignant Ovarian Neoplasm	Predictive	D	Supports Sensitivity Response	2	submitted	EID11728 To test for genes associated with PARPi response, a literature review of 79 publications was done, followed by CRISPR-Cas9 cell competition assays in combination with olaparib treatment in six EOC cel… (full text at CIViC) PMID 36307400 · Coelho et al., 2022 · Open in CIViC	civic
RAD51B Mutation1
Olaparib	Castration-Resistant Prostate Carcinoma	Predictive	A

Cohorts

Alteration frequency by cohort (7)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved7 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Atypical Small Cell Lung Cancer (MSK, Cancer Discov 2024) asclc_msk_2024	unmapped	Ssm	3	31	9.7%

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Olaparib for Metastatic Castration-Resistant Prostate Cancer.
· N Engl J Med · 2020 · PMID 32343890 · validated civic_curation pubmed