Variant · Fusion
LEUTX Fusion
CI-VAR-00001331Explore in graph →CIViC 3987
Curated evidence
Evidence by cancer (2 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 33344249
- Run
- ING-CIVIC-20260908-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Childhood Central Nervous System Embryonal Carcinoma1 | ||||||||
| CIC::LEUTX Fusion | (diagnostic) | Diagnostic | C | Supports Positive | 2 | submitted | EID10310This is a report about CIC-LEUTX gene fusion (CIC exon 20 to LEUTX exon 3 ) in a CNS embryonal tumor from a 2-year-old male, and the report also reviewed the clinical and pathological features of 3 ot… (full text at CIViC) PMID 33344249 · Hu et al., 2020 · Open in CIViC | civic |
| CIC-Rearranged Sarcoma1 | ||||||||
| CIC::DUX4 Fusion OR CIC::LEUTX Fusion OR CIC::NUTM1 Fusion OR CIC::NUTM2B Fusion OR ATXN1::NUTM1 Fusion OR ATXN1::NUTM2B Fusion OR DOCK1::DUX4 Fusion | (diagnostic) | Diagnostic | B | Supports Positive | 4 | submitted | EID12515The cohort included 44 CIC-rearranged sarcomas (CIC-RS), comprising 18 central nervous system (CNS) and 26 extra-CNS tumors. RNA sequencing (n=27) identified CIC::DUX4 (n=15), CIC::NUTM1 (n=4), CIC::L… | |
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available