Publication
Fluorouracil sensitivity in a head and neck squamous cell carcinoma with a somatic DPYD structural variant.
Authors not recorded
Cold Spring Harb Mol Case Stud2020PMID 31871216PMC6996515stubpubmedProvenance
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
No abstract stored. Read on PubMed
Linked entities
Linked entities (5)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 5
- cancerHead and Neck Squamous Cell Carcinomacivic_curation1.00
- drugFluorouracilcivic_curation1.00
- drugLeucovorincivic_curation1.00
- geneDPYDcivic_curation1.00
- variantDPYD EXON 11-19 DELETIONcivic_curation1.00
Curated evidence
Evidence citing this paper (1)
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 31871216
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| DPYD EXON 11-19 DELETION1 | ||||||||
| Fluorouracil + LeucovorinCombination | Head and Neck Squamous Cell Carcinoma | Predictive | C | Supports Sensitivity Response | 4 | accepted | EID7787A 69 year old patient diagnosed with HNSCC presented with an unresectable neck mass three months after surgery and adjuvant radiation therapy. A biopsy was taken for whole genome and transcriptome ana… (full text at CIViC) PMID 31871216 · Majounie et al., 2020 · Open in CIViC | civic |