Gene

DCC

DCC netrin 1 receptor

Explore in graph →CI-GENE-00042983HGNC:2701 ENSG00000187323 NCBI 1630 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
DCC EXPRESSION1
(prognostic)	Malignant Colorectal NeoplasmCURATED_BROADER	Prognostic	B	Supports Better Outcome	3	accepted	EID2972 Expression of DCC was a strong positive predictive factor for survival in both stage II and stage III colorectal carcinomas. In patients with stage II disease whose tumors expressed DCC, the five-year… (full text at CIViC) PMID 8929264 · Shibata et al., 1996 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (90)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved90 cohort rows (showing 40, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Bladder Cancer (TCGA, Cell 2017) blca_tcga_pub_2017	Bladder Urothelial Carcinoma	Ssm	28

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

The DCC protein and prognosis in colorectal cancer.
· N Engl J Med · 1996 · PMID 8929264 · validated civic_curation pubmed