Gene

CEBPA

CCAAT enhancer binding protein alpha

Explore in graph →CI-GENE-00040889HGNC:1833 ENSG00000245848 NCBI 1050 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (15)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–15 of 15 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
CEBPA BIALLELIC INACTIVATION1
(prognostic)	Acute Myeloid LeukemiaCURATED_BROADER	Prognostic	B	Supports Better Outcome	5	accepted	EID1512 In a study of 1,540 patients with Acute Myeloid Leukemia, 66 patients (4%) had a CEBPA (biallelic) mutation. In the absence of gene fusion products, patients with biallelic CEBPA mutations showed the… (full text at CIViC) PMID 27276561 · Papaemmanuil et al., 2016 · Open in CIViC	civic
CEBPA Mutation12
(prognostic)	Acute Myeloid LeukemiaCURATED_BROADER	Prognostic	B	Supports Better Outcome	4	accepted	EID167 In young patients (age 16-60) with previously untreated, cytogenetically normal acute myeloid leukemia, CEBPA mutation was significantly associated with complete remission in multivariate analysis (od…

Cohorts

Alteration frequency by cohort (41)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved41 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Colorectal Cancer (MSK, Cancer Discovery 2022) coadread_mskresistance_2022	Colorectal Adenocarcinoma	Ssm	7

Literature

Linked publications (11)

25 per page, newest first.

pubmedPublishedShowing 1–11 of 11 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Genomic Classification and Prognosis in Acute Myeloid Leukemia.
· N Engl J Med · 2016 · PMID 27276561 · validated civic_curation pubmed
Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia.
· N Engl J Med · 2008 · PMID 18450602 · validated civic_curation pubmed
Prevalence and prognostic implications of CEBPA mutations in pediatric acute myeloid leukemia (AML): a report from the Children's Oncology Group.
· Blood · 2009 · PMID 19304957 · validated civic_curation pubmed
Prognostic implications of CEBPA mutations in pediatric acute myeloid leukemia: a report from the Japanese Pediatric Leukemia/Lymphoma Study Group.
· Blood Cancer J · 2014 · PMID 25014773 · validated civic_curation

CEBPA N-TERMINAL FRAME SHIFT2
(prognostic)	Acute Myeloid LeukemiaCURATED_BROADER	Prognostic	B	Supports Better Outcome	3	accepted	EID169 Remission duration was significantly longer in younger (16-60), cytogenetically normal AML patients with CEBPA PMID 14726504 · Fröhling et al., 2004 · Open in CIViC	civic
OICR-9429	Acute Myeloid LeukemiaCURATED_BROADER	Predictive	D	Supports Sensitivity Response	3	accepted	EID1103 This preclinical study establishes that the p30 isoform of CEBPA expressed as a result of N-terminal truncating mutations preferentially interacts with WRD5, a component of the SET/MLL complex. Knockd… (full text at CIViC) PMID 26167872 · Grebien et al., 2015 · Open in CIViC	civic

CEBPA N-TERMINAL FRAME SHIFT2

(prognostic)

Acute Myeloid LeukemiaCURATED_BROADER

Prognostic

Supports Better Outcome

accepted

EID169

Remission duration was significantly longer in younger (16-60), cytogenetically normal AML patients with CEBPA

PMID 14726504 · Fröhling et al., 2004 · Open in CIViC

civic

OICR-9429

Acute Myeloid LeukemiaCURATED_BROADER

Predictive

Supports Sensitivity Response

accepted

EID1103

This preclinical study establishes that the p30 isoform of CEBPA expressed as a result of N-terminal truncating mutations preferentially interacts with WRD5, a component of the SET/MLL complex. Knockd… (full text at CIViC)

PMID 26167872 · Grebien et al., 2015 · Open in CIViC

civic